| OR (95%-CI) low GRS1
| OR (95%-CI) high GRS1
|
p-value2 (GRSxE) |
---|
PM2.5
| 0.76 (0.35–1.65) | 2.64 (1.52–4.58) | 0.014 |
PM2.5 absorbance | 0.87 (0.52–1.49) | 1.77 (1.14–2.75) | 0.063 |
PM10
| 0.99 (0.56–1.77) | 2.04 (1.30–3.19) | 0.102 |
NO2
| 0.92 (0.47–1.80) | 2.05 (1.23–3.41) | 0.078 |
- Association between air pollution exposure and lung inflammation in women with a low weighted GRS vs. women with a high weighted GRS for ER stress. Air pollution exposures per increase of IQR: PM2.5: fine inhalable particles, with diameters that are generally 2.5 μm and smaller; PM2.5 absorbance: filter absorbance of PM2.5 (soot); PM10: inhalable particles, with diameters that are generally 10 μm and smaller; NO2: Nitrogen dioxide
- All models were adjusted for age, BMI (kg/m2), smoking history, passive smoking, level of education and indoor air pollution (heating with fossil fuels and exposure to indoor mold)
- Lung inflammation: levels of leukotriene (LT) B4 measured in induced sputum (low vs. high, cut point at 3rd quartile)
-
1: weighted GRS dichotomized at its median for a better interpretation of interaction findings
-
2: p-values are given for the interaction term between the weighted GRS and air pollution (compare Table 2)