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Table 1 Overview about the six risk SNPs (Design 1) included in the simulation study

From: Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression

Mean OR(GxE)

SNP

MAF

OR (G)

p-value (G)

OR (E)

p-value (E)

OR (GxE)

p-value (GxE)

1.01

CFHrs1061170

0.50

1.32

<0.001

1.03

<0.001

1.01

0.020

LOCrs10490924

0.33

1.76

<0.001

1.03

<0.001

1.01

0.002

CFHrs1410996

0.30

1.32

<0.001

1.03

<0.001

1.01

0.075

C2rs9332739

0.07

3.08

<0.001

1.03

<0.001

1.01

0.422

CFBrs641153

0.12

1.13

0.134

1.03

<0.001

1.03

0.001

CFHrs2230199

0.27

1.28

<0.001

1.03

<0.001

1.01

0.082

1.04

CFHrs1061170

0.50

1.32

<0.001

1.05

<0.001

1.02

<0.001

LOCrs10490924

0.33

1.76

<0.001

1.05

<0.001

1.04

<0.001

CFHrs1410996

0.30

1.32

<0.001

1.05

<0.001

1.02

0.001

C2rs9332739

0.07

3.08

<0.001

1.05

<0.001

1.03

0.248

CFBrs641153

0.12

1.13

0.134

1.05

<0.001

1.06

<0.001

CFHrs2230199

0.27

1.28

<0.001

1.05

<0.001

1.06

<0.001

1.05

CFHrs1061170

0.50

1.32

<0.001

1.12

<0.001

1.03

<0.001

LOCrs10490924

0.33

1.76

<0.001

1.12

<0.001

1.05

<0.001

CFHrs1410996

0.30

1.32

<0.001

1.12

<0.001

1.03

<0.001

C2rs9332739

0.07

3.08

<0.001

1.12

<0.001

1.06

0.012

CFBrs641153

0.12

1.13

0.134

1.12

<0.001

1.07

<0.001

CFHrs2230199

0.27

1.28

<0.001

1.12

<0.001

1.07

<0.001

  1. Minor allele frequency (MAF), estimated OR and p-values for the main effects of each SNP (G) and environmental factor (E) and gene-environment interaction (GxE) in the dataset from the R-package PredictABEL (n = 10,000), which we extended by a simulated gene-environment interaction term (GxE). For the gene-environment interaction term, we generated a continuous environmental predictor variable E which has a different effect on disease risk in persons with different genotypes of the six independent genetic risk factors