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Fig. 2 | BMC Genetics

Fig. 2

From: In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway

Fig. 2

Loss of DmManf alters wing morphology. a Knockdown of DmManf with MS1096-GAL4 caused a “bent-up” phenotype in which the edges of wings were curled upwards (b3). DmManf knockdown in heterozygous DmManf Δ96 mutant background showed more severe wing phenotype, even total loss of the wing blade in adult males (b2 and b4). Wing phenotype was rescued by overexpression of DmManf (c1-c2), HsMANF (d1-d4) and HsCDNF (e1-e4). MS1096-GAL4 flies were used as a wild type control (a1-a4). Scale bar 1 mm. b Knockdown of DmManf with semi-ubiquitous driver 69B-GAL4 showed a blistered wing phenotype in adult females. Males showed lethal phenotype in wild type background, females in heterozygous DmManf Δ96 mutant background. Scale bar 100 μm

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