Table 4 The significant exercise-regulated molecular pathways identified fallowing training in Arabian horses
From: Transcriptome profiling of Arabian horse blood during training regimens
Pathway | Kegg number | Gene N | Gene symbol | p | Gene N | Gene symbol | p | Gene N | Gene symbol | p |
|---|---|---|---|---|---|---|---|---|---|---|
Comparison | T1 vs T2 | T2 vs T3 | T0 vs T3 | |||||||
Jak-STAT signaling pathway | ecb04630 | 4 | BCL2, IL6ST, PIK3CG, PTPN11, | 0.03 | 6 | BCL2, CCND2, IL6ST, IL7R, PIK3CG, PTPN11, | 0.01 | |||
PI3K-Akt signaling pathway | ecb04151 | 6 | BCL2, FOXO3, GNBa, ITGA4, PIK3AP1, PIK3CG, | 0.01 | 11 | BCL2, CCND2, FOXO3, GNB4, IL7R, ITGA4, PIK3AP1, PIK3CG, PPP2R5E, YWHAG, GNGT2 | 0.001 | |||
cAMP signaling pathway | ecb04024 | 2 | PDE3B, PIK3CG | 0.04 | 7 | ATP2B, CAMK4, NFATC1, PDE3B, PDE4A, PIK3CG, PPP1R12A | 0.003 | |||
FoxO signaling pathway | ecb04068 | 4 | ATM, FOXO3, PIK3CG, TGFBR1, | 0.03 | 8 | ATM, CCND2, FOXO3, IL7R, STK4, PIK3CG, S1PR4, TGFBR1 | 0.001 | |||
Glycerophospholipid metabolism | ecb00564 | 4 | AGPAT5, LGPAT1, GPD1, PLA2G4F | 0.001 | 4 | AGPAT3, AGPAT5, GPD2, LPGAT1, | 0.01 | 5 | AGPAT3, AGPAT5, GPD2, LPGAT1, PCYT1A | 0.002 |
Insulin signaling pathway | ecb04910 | 4 | CBL, CBLB, PDE3B, PIK3CG | 0.02 | 5 | CBL, FASN, CBLB, PDE3B, PIK3CG | 0.02 | |||
Calcium signaling pathway | ecb04020 | 2 | CYSLTR1, SLC25A4 | 0.01 | 3 | ITPR1, ITPR2, CYSLTR1 | 0.03 | 5 | ATP2A2, ATP2B4, CAMK4, ITPR1, ITPR2, | 0.03 |
Regulation of actin cytoskeleton | ecb04810 | 1 | MYLPF | ns | 6 | ARHGEF6, IQGAP2, ITGA4, PAK2, PIK3CG, SSH2, | 0.01 | 8 | ARHGEF6, IQGAP2, ITGA4, MSN, PAK2, PIK3CG, SSH2, PPP1R12A | 0.02 |
Notch signaling pathway | ecb04330 | 2 | KAT2B, RBPJ | ns | 5 | KAT2B, NCOR2, NOTCH1, NOTCH2, RBPJ | 0.001 | |||
Hypertrophic cardiomyopathy (HCM) | ecb05410 | 4 | CACNB1, TPM1, TPM2, TTN, | 0.03 | 1 | ITGA4 | ns | 1 | ITGA4 | ns |