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Fig. 3 | BMC Genetics

Fig. 3

From: Opportunities and challenges of whole-genome and -exome sequencing

Fig. 3

Course of a typical trio exome project yielding several VUS and benefit of MME for variant selection. Filter by mode of inheritance: recessive or dominant; by variant consequence: missense, nonsense, splice-site, start-loss or stop-loss; by frequency: maximum minor allele frequency of 1% in various databases (ExAC, EVS, in-house controls)

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