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Fig. 2 | BMC Genetics

Fig. 2

From: Opportunities and challenges of whole-genome and -exome sequencing

Fig. 2

a Top: Range of IBD-relevant variants based on genetic complexity underlying the disease and variant penetrance. Bottom: Overview of identified IBD genes ranging from monogenic to complex forms based on the highest known penetrance for each gene. For both NOD2 and PRDM1, for example, both common and rare variants have been identified as disease-relevant in patients [110, 111]. b Timeline of gene discovery for IBD [112137]. Top graph shows cumulative number of genes separated by technology (log scale)

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