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Table 2 Overrepresented (BH adjusted p-value < 0.05) GO terms (biological processes, molecular functions, cellular compartments) that characterize functional groups of genes presented in Fig. 2b.

From: A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Functional group GO category GO class Number of genes from the compendium annotated by the category Fold Enrichment BH adjusted p-value
Transmembrane receptors GO:0004888 ~transmembrane receptor activity Molecular function 89 2.09 1.6E-09
Transcription factors GO:0003700 ~ transcription factor activity Molecular function 52 1.63 1.1E-02
Signaling molecules (hormones, neuropeptides, cytokines, etc.) GO:0005179 ~ hormone activity Molecular function 37 10.48 1.5E-24
GO:0005184 ~ neuropeptide hormone activity Molecular function 15 19.95 7.6E-14
GO:0005125 ~ cytokine activity Molecular function 16 2.51 3.2E-02
Signal transduction GO:0004871 ~ signal transducer activity Molecular function 139 1.87 3.2E-12
Cilium or BBSome GO:0060271 ~ cilium morphogenesis Biological process 10 8.77 1.5E-05
GO:0034464 ~ BBSome Cellular component 7 31.56 1.8E-07
Lipid localization GO:0008289 ~ lipid binding Molecular function 34 2.31 3.9E-04
Transcriptional coregulators Nonea
Enzymes (regulatory) None
Enzymes (metabolic) None
  1. The list of 578 genes from the compendium was analyzed with the DAVID-tool. The significance level for the BH adjusted p-value was 0.05
  2. aNone – No overrepresented GO terms were found