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Table 3 Genes differentially expressed in ISIAH versus WAG renal medulla and annotated in Rat Genome Database as associated with kidney diseases

From: The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

Gene symbol

NCBI gene ID

Gene name

log2 fold change ISIAH/WAG

Acsm3

24763

acyl-CoA synthetase medium-chain family member 3

3.40

Adipoq c,d

246253

adiponectin, C1Q and collagen domain containing

1.17

Agtr1a a,c,d

24180

angiotensin II receptor, type 1a

−0.47

Ak4 c

29223

adenylate kinase 4

0.63

Alpl

25586

alkaline phosphatase, liver/bone/kidney

0.53

Amacr

25284

alpha-methylacyl-CoA racemase

0.50

Angpt2 a

89805

angiopoietin 2

−0.79

Anxa2

56611

annexin A2

−0.45

Apoh d

287774

apolipoprotein H (beta-2-glycoprotein I)

−1.52

Aqp2 d

25386

aquaporin 2 (collecting duct)

−0.47

Baat

29725

bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

0.78

Car2

54231

carbonic anhydrase 2

0.53

Cftr

24255

cystic fibrosis transmembrane conductance regulator

−1.22

Cldn19

298487

claudin 19

−0.53

Clu a,c,d

24854

clusterin

−0.80

Col3a1 a,c

84032

collagen, type III, alpha 1

−0.64

Col4a5

363457

collagen, type IV, alpha 5

−0.45

Comt

24267

catechol-O-methyltransferase

−0.67

Csf1r c,d

307403

colony stimulating factor 1 receptor

−0.73

Cst3 d

25307

cystatin C

−0.50

Cubn d

80848

cubilin (intrinsic factor-cobalamin receptor)

0.68

Cyp1a1 c

24296

cytochrome P450, family 1, subfamily a, polypeptide 1

−0.51

Cyp4a3

298423

cytochrome P450, family 4, subfamily a, polypeptide 3

0.52

Dusp1

114856

dual specificity phosphatase 1

−0.71

Ebag9

299864

estrogen receptor binding site associated, antigen, 9

0.49

Ephx2 c,d

65030

epoxide hydrolase 2, cytoplasmic

4.52

F2 c,d

29251

coagulation factor II

−0.93

Fbn1 a,d

83727

fibrillin 1

−0.61

Fga c

361969

fibrinogen alpha chain

0.85

Fhit

60398

fragile histidine triad

1.58

Fmod d

64507

fibromodulin

−1.09

Fn1 a,c,d

25661

fibronectin 1

−0.98

Gatm c

81660

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

0.86

Gja1

24392

gap junction protein, alpha 1

0.99

Gpc1

58920

glypican 1

−0.72

Gstp1 c

24426

glutathione S-transferase pi 1

0.53

Gtpbp4 c

114300

GTP binding protein 4

3.01

Hao1

311446

hydroxyacid oxidase (glycolate oxidase) 1

−1.60

Hgf d

24446

hepatocyte growth factor

−0.77

Igf1 d

24482

insulin-like growth factor 1

−0.75

Igfbp1 d

25685

insulin-like growth factor binding protein 1

1.26

Il4r

25084

interleukin 4 receptor

0.64

Lama2

309368

laminin, alpha 2

−0.58

Lgals1

56646

lectin, galactoside-binding, soluble, 1

0.88

Lrp1 a

299858

low density lipoprotein receptor-related protein 1

−0.53

Lrp5

293649

low density lipoprotein receptor-related protein 5

−0.47

Ltbp1

59107

latent transforming growth factor beta binding protein 1

−0.57

Mif

81683

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

0.55

Mme

24590

membrane metallo-endopeptidase

1.35

Mmp2 a, c

81686

matrix metallopeptidase 2

−0.54

Mmp9 a, d

81687

matrix metallopeptidase 9

−2.00

Mok

362787

MOK protein kinase

−0.93

Mthfr b, c, d

362657

methylenetetrahydrofolate reductase (NAD(P)H)

0.49

Nos3 c, d

24600

nitric oxide synthase 3, endothelial cell

−0.55

Nox4 d

85431

NADPH oxidase 4

0.50

Nphs2 a

170672

nephrosis 2, idiopathic, steroid-resistant

0.57

Pecam1 d

29583

platelet/endothelial cell adhesion molecule 1

−0.45

Pla2g4a

24653

phospholipase A2, group IVA (cytosolic, calcium-dependent)

−0.69

Ptgds b, d

25526

prostaglandin D2 synthase (brain)

−0.78

Ptk2b

50646

protein tyrosine kinase 2 beta

−0.79

Rap1gap a

313644

Rap1 GTPase-activating protein

−0.60

Retn c, d

246250

resistin

expression was detected only in ISIAH rats

RT1-Bb

309622

RT1 class II, locus Bb

−1.26

Serpinf1 d

287526

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

−2.10

Serping1

295703

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

0.56

Sfrp1

84402

secreted frizzled-related protein 1

−0.61

Slc17a2

306950

solute carrier family 17, member 2

0.59

Slc19a3 c

316559

solute carrier family 19 (thiamine transporter), member 3

1.00

Slc5a2

64522

solute carrier family 5 (sodium/glucose cotransporter), member 2

0.64

Slc6a19

664630

solute carrier family 6 (neutral amino acid transporter), member 19

0.48

Slit2

360272

slit homolog 2 (Drosophila)

0.45

Sod3 d

25352

superoxide dismutase 3, extracellular

0.56

Tf d

24825

transferrin

−1.43

Timp2 d

29543

TIMP metallopeptidase inhibitor 2

−0.52

Vcam1 c,d

25361

vascular cell adhesion molecule 1

−0.86

Vtn d

29169

vitronectin

−1.18

  1. Genes associated with: arenal fibrosis; bnephrosclerosis; crenal insufficiency, ddiabetic nephropathy; ISIAH and WAG – rat strains used in the study