Table 2 Genes differentially expressed in ISIAH and WAG renal medulla and referred to in Databases as associated with hypertension and blood pressure regulation

  Acsm3 ^e

24763

acyl-CoA synthetase medium-chain family member 3

3.40

  Adipoq ^c,d,e

246253

adiponectin, C1Q and collagen domain containing

1.17

  Adra1b ^c

24173

adrenoceptor alpha 1B

−1.31

  Adra2a

25083

adrenoceptor alpha 2°

−1.15

  Agtr1a ^a,c,d,e

24180

angiotensin II receptor, type 1°

−0.47

  Alas1

65155

aminolevulinate, delta-, synthase 1

0.74

  Angpt2 ^e

89805

angiopoietin 2

−0.79

  Aqp2 ^d

25386

aquaporin 2 (collecting duct)

−0.47

  Aqp4 ^e

25293

aquaporin 4

−0.59

  Clu ^d,e

24854

clusterin, transcript variant X1

−0.80

  Cnr1 ^c

25248

cannabinoid receptor 1 (brain)

−0.58

  Comt

24267

catechol-O-methyltransferase

−0.67

  Corin

289596

corin, serine peptidase

−1.04

  Cst3 ^c,d,e

25307

cystatin C

−0.50

  Cyp1a1 ^e

24296

cytochrome P450, family 1, subfamily a, polypeptide 1

−0.51

  Cyp4f1

56266

cytochrome P450, family 4, subfamily f, polypeptide 1

0.60

  Dio2 ^c

65162

deiodinase, iodothyronine, type II

−2.56

  Dusp1 ^e

114856

dual specificity phosphatase 1

−0.71

  Ebag9

299864

estrogen receptor binding site associated, antigen, 9

0.49

  Emilin1

298845

elastin microfibril interfacer 1

−0.65

  Ephx1 ^e

25315

epoxide hydrolase 1, microsomal (xenobiotic)

0.70

  Ephx2 ^c,d

65030

epoxide hydrolase 2, cytoplasmic

4.52

  F2 ^{d, e}

29251

coagulation factor II

−0.93

  Fbn1 ^d

83727

fibrillin 1, transcript variant X1

−0.61

  Fn1 ^a,d,e

25661

fibronectin 1

−0.98

  Gja1 ^a,e

24392

gap junction protein, alpha 1

0.99

  Gstm2

24424

glutathione S-transferase mu 2

−0.76

  Gstp1 ^e

24426

glutathione S-transferase pi 1

0.53

  Hgf ^c,d,e

24446

hepatocyte growth factor

−0.77

  Hsd17b4 ^e

79244

hydroxysteroid (17-beta) dehydrogenase 4

0.52

  Igf1 ^d,e

24482

insulin-like growth factor 1

−0.75

  Itgav ^c

296456

integrin, alpha V

−0.60

  Lama2 ^a

309368

laminin, alpha 2

−0.58

  Lox

24914

lysyl oxidase

−0.81

  Mif ^c,e

81683

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

0.55

  Mmp2 ^a,e

81686

matrix metallopeptidase 2

−0.54

  Mmp9 ^ad,e

81687

matrix metallopeptidase 9

−2.00

  Mthfr ^b,d,e

362657

methylenetetrahydrofolate reductase (NAD(P)H)

0.49

  Nos3 ^a,c,d,e

24600

nitric oxide synthase 3, endothelial cell

−0.55

  Nox4 ^d

85431

NADPH oxidase 4

0.50

  Pappa

313262

pregnancy-associated plasma protein A

−0.68

  Pecam1 ^d,e

29583

platelet/endothelial cell adhesion molecule 1

−0.45

  Ptgds ^b,c,d

25526

prostaglandin D2 synthase (brain)

−0.78

  Ptk2b ^c,e

50646

protein tyrosine kinase 2 beta

−0.79

  Retn ^c,d,e

246250

resistin

expression was detected only in ISIAH rats

  Rnpep

81761

arginyl aminopeptidase (aminopeptidase B)

−0.47

  RT1-Bb ^e

309622

RT1 class II, locus Bb

−1.26

  Serpine2

29366

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

−0.55

  Slc26a4

29440

solute carrier family 26 (anion exchanger), member 4

0.59

  Slc2a4 ^c

25139

solute carrier family 2 (facilitated glucose transporter), member 4

−0.76

  Slc5a2

64522

solute carrier family 5 (sodium/glucose cotransporter), member 2

0.64

  Slc6a19

664630

solute carrier family 6 (neutral amino acid transporter), member 19

0.48

  Slc8a1

29715

solute carrier family 8 (sodium/calcium exchanger), member 1

0.53

  Slc9a3r2

116501

solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2

−0.49

  Sod3 ^c,d

25352

superoxide dismutase 3, extracellular

0.56

  Tacr3

24808

tachykinin receptor 3

−1.22

  Tf ^c,d,e

24825

transferrin

−1.43

  Vcam1 ^c,d,e

25361

vascular cell adhesion molecule 1

−0.86

  Col1a2 ^e

84352

collagen, type I, alpha 2

−0.53

  Guca2b

64055

guanylate cyclase activator 2B

2.03

  P2rx4

29659

purinergic receptor P2X, ligand-gated ion channel 4

−1.41

  Pcsk5

116548

proprotein convertase subtilisin/kexin type 5

0.73