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Table 2 Genes differentially expressed in ISIAH and WAG renal medulla and referred to in Databases as associated with hypertension and blood pressure regulation

From: The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

Gene symbol NCBI gene ID Gene name log2 fold_change ISIAH/WAG
Rat Genome Database
  Acsm3 e 24763 acyl-CoA synthetase medium-chain family member 3 3.40
  Adipoq c,d,e 246253 adiponectin, C1Q and collagen domain containing 1.17
  Adra1b c 24173 adrenoceptor alpha 1B −1.31
  Adra2a 25083 adrenoceptor alpha 2° −1.15
  Agtr1a a,c,d,e 24180 angiotensin II receptor, type 1° −0.47
  Alas1 65155 aminolevulinate, delta-, synthase 1 0.74
  Angpt2 e 89805 angiopoietin 2 −0.79
  Aqp2 d 25386 aquaporin 2 (collecting duct) −0.47
  Aqp4 e 25293 aquaporin 4 −0.59
  Clu d,e 24854 clusterin, transcript variant X1 −0.80
  Cnr1 c 25248 cannabinoid receptor 1 (brain) −0.58
  Comt 24267 catechol-O-methyltransferase −0.67
  Corin 289596 corin, serine peptidase −1.04
  Cst3 c,d,e 25307 cystatin C −0.50
  Cyp1a1 e 24296 cytochrome P450, family 1, subfamily a, polypeptide 1 −0.51
  Cyp4f1 56266 cytochrome P450, family 4, subfamily f, polypeptide 1 0.60
  Dio2 c 65162 deiodinase, iodothyronine, type II −2.56
  Dusp1 e 114856 dual specificity phosphatase 1 −0.71
  Ebag9 299864 estrogen receptor binding site associated, antigen, 9 0.49
  Emilin1 298845 elastin microfibril interfacer 1 −0.65
  Ephx1 e 25315 epoxide hydrolase 1, microsomal (xenobiotic) 0.70
  Ephx2 c,d 65030 epoxide hydrolase 2, cytoplasmic 4.52
  F2 d, e 29251 coagulation factor II −0.93
  Fbn1 d 83727 fibrillin 1, transcript variant X1 −0.61
  Fn1 a,d,e 25661 fibronectin 1 −0.98
  Gja1 a,e 24392 gap junction protein, alpha 1 0.99
  Gstm2 24424 glutathione S-transferase mu 2 −0.76
  Gstp1 e 24426 glutathione S-transferase pi 1 0.53
  Hgf c,d,e 24446 hepatocyte growth factor −0.77
  Hsd17b4 e 79244 hydroxysteroid (17-beta) dehydrogenase 4 0.52
  Igf1 d,e 24482 insulin-like growth factor 1 −0.75
  Itgav c 296456 integrin, alpha V −0.60
  Lama2 a 309368 laminin, alpha 2 −0.58
  Lox 24914 lysyl oxidase −0.81
  Mif c,e 81683 macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.55
  Mmp2 a,e 81686 matrix metallopeptidase 2 −0.54
  Mmp9 ad,e 81687 matrix metallopeptidase 9 −2.00
  Mthfr b,d,e 362657 methylenetetrahydrofolate reductase (NAD(P)H) 0.49
  Nos3 a,c,d,e 24600 nitric oxide synthase 3, endothelial cell −0.55
  Nox4 d 85431 NADPH oxidase 4 0.50
  Pappa 313262 pregnancy-associated plasma protein A −0.68
  Pecam1 d,e 29583 platelet/endothelial cell adhesion molecule 1 −0.45
  Ptgds b,c,d 25526 prostaglandin D2 synthase (brain) −0.78
  Ptk2b c,e 50646 protein tyrosine kinase 2 beta −0.79
  Retn c,d,e 246250 resistin expression was detected only in ISIAH rats
  Rnpep 81761 arginyl aminopeptidase (aminopeptidase B) −0.47
  RT1-Bb e 309622 RT1 class II, locus Bb −1.26
  Serpine2 29366 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 −0.55
  Slc26a4 29440 solute carrier family 26 (anion exchanger), member 4 0.59
  Slc2a4 c 25139 solute carrier family 2 (facilitated glucose transporter), member 4 −0.76
  Slc5a2 64522 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.64
  Slc6a19 664630 solute carrier family 6 (neutral amino acid transporter), member 19 0.48
  Slc8a1 29715 solute carrier family 8 (sodium/calcium exchanger), member 1 0.53
  Slc9a3r2 116501 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 −0.49
  Sod3 c,d 25352 superoxide dismutase 3, extracellular 0.56
  Tacr3 24808 tachykinin receptor 3 −1.22
  Tf c,d,e 24825 transferrin −1.43
  Vcam1 c,d,e 25361 vascular cell adhesion molecule 1 −0.86
DAVID
  Col1a2 e 84352 collagen, type I, alpha 2 −0.53
  Guca2b 64055 guanylate cyclase activator 2B 2.03
  P2rx4 29659 purinergic receptor P2X, ligand-gated ion channel 4 −1.41
  Pcsk5 116548 proprotein convertase subtilisin/kexin type 5 0.73
  1. ISIAH and WAG – rat strains used in the study. DAVID – Database for Annotation, Visualization and Integrated Discovery (http://david.abcc.ncifcrf.gov/)
  2. Genes associated with: arenal hypertension; bnephrosclerosis; cinsulin resistance; ddiabetic nephropathy; eimmune system diseases
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BMC Genomic Data

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