Fig. 4

Retinas of 10-month-old WAG/OXYS-1.2 a and WAG/OXYS-1.1 b rats. The thinning of the outer nuclear layer with a reduction in the number of the photoreceptors in the retina of a 16-month-old WAG/OXYS-1.2 rat c. a The open intraretinal vessels (red arrows). b Open intraretinal capillaries (red arrows); the flattening of the RPE cells, RPE cells containing a nucleus with pyknosis (white dashed arrows); migration of mononuclear phagocytes within the subretinal space with RPE detachment (black dashed arrow). c Open intraretinal capillaries (red arrows); the flattening of the RPE cells, RPE cells containing a nucleus with pyknosis (black arrows); the destructive changes in neurosensory and associative neurons (black dashed arrows). Abbreviations: OPL: outer plexiform layer, INL: inner nuclear layer; IPL: the inner plexiform layer; ONL: outer nuclear layer; GL: ganglion cell layer, RPE: retinal pigment epithelium, PhL: photoreceptor layer. The scale bar is 10 μm