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Table 7 Stratified analysis based on ethnicity for the association between ABCB1 C3435T polymorphism and breast cancer risk

From: Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis

Ethnicity

Cases/ controls

Recessive model

TT vs. CC + CT

Dominant model

CC vs. TT + CT

Homozygote model

TT vs. CC

Allele contrast model

T vs. C

OR (95 % CI); P value

Ph

OR (95 % CI); P value

Ph

OR (95 % CI); P value

Ph

OR (95 % CI); P value

Ph

Fixed effects

Random effects

Fixed effects

Random effects

Fixed effects

Random effects

Fixed effects

Random effects

Asian

4,835/7,334

1.405 (1.145 to 1.725) ; 0.001

1.405 (1.144 to 1.725) ; 0.001

0.3888

0.876 (0.742 to 1.033) ; 0.116

0.644 (0.271 to 1.528) ; 0.318

0.0573

1.458 1.156 to 1.840) ; 0.001

1.918 (0.809 to 4.545) ; 0.139

0.0816

1.175 (1.051 to 1.313) ; 0.005

1.346 (0.887 to 2.042) ; 0.163

0.0706

Caucasian

4,123/6,591

1.093 (1.001 to 1.194) ; 0.048

1.124 (1.002 to 1.262) ; 0.047

0.3993

0.954 (0.869 to 1.049) ; 0.333

0.844 (0.677 to 1.052) ; 0.131

0.0857

1.119 (1.000 to 1.252) ; 0.050

1.427 (1.079 to 1.886) ; 0.013

0.0836

1.054 (0.996 to 1.114) ; 0.068

1.147 (1.014 to 1.298) ; 0.030

0.1382

Mixed

312/335

0.666 (0.422 to 1.054) ; 0.083

0.667 (0.391 to 1.138) ; 0.137

0.2640

0.933 (0.651 to 1.339) ; 0.708

0.935 (0.653 to 1.338) ; 0.712

0.3854

0.755 (0.449 to 1.269) ; 0.289

0.724 (0.368 to 1.422) ; 0.348

0.2221

0.923 (0.729 to 1.169) ; 0.506

0.908 (0.673 to 1.225) ; 0.528

0.2197

North Africa

250/258

2.028 (1.220 to 3.371) ; 0.006

2.026 (1.218 to 3.369) ; 0.007

0.7438

0.841 (0.587 to 1.204) ; 0.343

0.940 (0.466 to 1.896) ; 0.864

0.0822

2.072 (1.196 to 3.590) ; 0.009

2.072 (1.193 to 3.596) ; 0.010

0.3610

1.312 (1.018 to 1.690) ; 0.036

1.241 (0.826 to 1.863) ; 0.298

0.1572

  1. Values in italic are statistically significant (P value <0.05); Random effects model was used when Ph < 0.05 otherwise fixed effects model was used
  2. CC homozygous wild-type, CT heterozygous, TT homozygous mutant, OR Odd Ratio, CI Confidence Interval; Ph: P value of Q test for heterogeneity test