From: An RGS2 3′UTR polymorphism is associated with preeclampsia in overweight women
Preeclampsia | Control | |||||
---|---|---|---|---|---|---|
Primipara | Multipara | Primipara | Multipara | Primipara | Multipara | |
(n = 987) | (n = 352) | (n = 377) | (n = 320) | P values | P values | |
Maternal characteristics | ||||||
Age, y | 30 (26/33) | 33 (30/38) | 29 (25/32) | 31 (28/35) | 0.020 | <0.001 |
Body mass index, kg/m2 | 23.6 (21.2/27.3) [985] | 24.8 (22.1/29.4) [351] | 23.0 (21.0/25.7) | 22.8 (20.7/26.2) | 0.006 | <0.001 |
Highest systolic blood pressure, mmHg | 165 (153/178) | 166 (156/180) | 126 (119/134) | 124 (117/131) | <0.001 | <0.001 |
Highest diastolic blood pressure, mmHg | 109 (104/116) | 109 (103/116) | 83 (78/88) | 81 (77/86) | <0.001 | <0.001 |
Highest proteinuria, g/24 h | 3.1 (1.4/6.2) [887] | 2.9 (1.1/5.6) [305] | 1.0 (0.8/1.6) [4] | 0.6 [2] | N/A | N/A |
Smoking before pregnancy | 172 (18.3) [941] | 48 (14.6) [328] | 90 (24.8) [363] | 44 (14.5) [304] | 0.008 | 0.954 |
Smoking during pregnancy | 58 (6.1) [948] | 26 (7.8) [333] | 28 (7.5) [371] | 26 (8.4) [308] | 0.345 | 0.769 |
Chronic hypertension | 151 (15.3) | 85 (24.1) | … | … | … | … |
Gestational diabetes mellitus | 116 (11.8) | 69 (19.6) | 29 (7.7) | 24 (7.5) | 0.030 | <0.001 |
Pregestational diabetes mellitus | 24 (2.4) | 16 (4.5) | 4 (1.1) | 1 (0.3) | 0.136 | <0.001 |
Placental weight, g | 495 (400/600) [951] | 500 (390/615) [338] | 590 (500/669) [363] | 628 (554/720) [314] | <0.001 | <0.001 |
Placental insufficiency | 94 (9.5) | 50 (14.2) | … | … | … | … |
Perinatal characteristics | ||||||
Gestational age at birth, weeks | 37.9 (35.4/39.3) [986] | 37.4 (34.6/39.0) | 40.6 (39.6/41.3) | 40.3 (39.4/41.1) | <0.001 | <0.001 |
Birth weight, g | 2775 (2185/3280) | 2790 (1882/3384) | 3520 (3245/3851) | 3730 (3416/4022) | <0.001 | <0.001 |
Relative birth weight (SD) | −1.1 (−1.9/−0.4) [986] | −1.1 (−1.9/0.0) [350] | −0.2 (−0.7/0.5) | 0.3 (−0.3/0.9) | <0.001 | <0.001 |