Risk score (number of SNPs in risk score) | Peak weight velocityb | BMI at adiposity peakb | Age at adiposity peakb | |||
---|---|---|---|---|---|---|
Beta (CI 95Â %) | P-value | Beta (CI 95Â %) | P-value | Beta (CI 95Â %) | P-value | |
Main risk scores* | ||||||
 Adult BMI (N = 97) | 0.027 (−0.004; 0.058) | 0.093 | 0.048 (0.015; 0.081) | 0.005 | 0.015 (−0.021; 0.051) | 0.418 |
 Secondary risk scores | ||||||
 Adult WHR (N = 47) | −0.022 (−0.054; 0.010) | 0.180 | −0.010 (−0.044; 0.025) | 0.587 | −0.016 (−0.053; 0.022) | 0.411 |
 Child BMI (N = 15) | 0.038 (0.007; 0.070) | 0.018 | 0.039 (0.006; 0.073) | 0.023 | 0.027 (−0.010; 0.063) | 0.153 |
Adult BMI pathway genetic risk scores** | ||||||
Neuronal | ||||||
 Neuronal developmental processes (N = 29) | 0.036 (0.003; 0.070) | 0.031 | 0.049 (0.013; 0.084) | 0.007 | −0.020 (−0.058; 0.019) | 0.311 |
 Neurotransmission (N = 10) | −0.009 (−0.040; 0.022) | 0.558 | −0.001 (−0.034; 0.032) | 0.948 | 0.002 (−0.034; 0.038) | 0.901 |
 Hypothalamic expression and regulation (N = 13) | 0.001 (−0.030; 0.033) | 0.932 | 0.008 (−0.025; 0.042) | 0.637 | 0.023 (−0.013; 0.059) | 0.203 |
 Neuronal expression (N = 12) | −0.034 (−0.065; −0.003) | 0.034 | −0.010 (−0.044; 0.024) | 0.559 | 0.026 (−0.010; 0.062) | 0.159 |
 Lipid biosynthesis and metabolism (N = 10) | 0.002 (−0.030; 0.033) | 0.918 | 0.006 (−0.028; 0.040) | 0.358 | 0.020 (−0.017; 0.056) | 0.291 |
 Bone development (N = 9) | 0.017 (−0.014; 0.048) | 0.290 | 0.017 (−0.017; 0.050) | 0.336 | 0.001 (−0.035; 0.037) | 0.957 |
Signaling | ||||||
 MAPK1/extracellular signal-regulated kinases (N = 9) | 0.009 (−0.022; 0.040) | 0.579 | 0.008 (−0.025; 0.042) | 0.625 | 0.011 (−0.025; 0.047) | 0.534 |
 JAK (N = 2) | −0.007 (−0.038; 0.025) | 0.679 | −0.005 (−0.038; 0.029) | 0.779 | −0.006 (−0.042; 0.030) | 0.750 |
 CyclicAMP (N = 5) | −0.020 (−0.052; 0.013) | 0.233 | 0.019 (−0.015; 0.054) | 0.368 | −0.016 (−0.053; 0.021) | 0.391 |
 WNTSignaling (N = 6) | 0.033 (0.001; 0.064) | 0.041 | 0.017 (−0.016; 0.051) | 0.311 | 0.019 (−0.017; 0.055) | 0.293 |
G-protein coupled receptor | ||||||
 Notch signaling (N = 2) | 0.010 (−0.021; 0.041) | 0.531 | 0.009 (−0.024; 0.043) | 0.581 | 0.012 (−0.024; 0.048) | 0.508 |
 Mitochondrial (N = 8) | 0.010 (−0.023; 0.043) | 0.559 | 0.004 (−0.032; 0.039) | 0.840 | 0.039 (0.001; 0.077) | 0.046 |
 Retinoic acid receptors (N = 6) | 0.019 (−0.013; 0.050) | 0.245 | 0.025 (−0.009; 0.058) | 0.144 | 0.019 (−0.017; 0.055) | 0.308 |
 Endocytosis/exocytosis (N = 14) | 0.004 (−0.027; 0.036) | 0.778 | 0.005 (−0.028; 0.038) | 0.776 | 0.007 (−0.029; 0.043) | 0.699 |
 Eye-related (N = 5) | 0.010 (−0.022; 0.042) | 0.548 | 0.010 (−0.025; 0.045) | 0.567 | −0.030 (−0.067; 0.007) | 0.116 |
 Tumorigenesis (N = 11) | 0.018 (−0.015; 0.050) | 0.285 | 0.018 (−0.017; 0.052) | 0.320 | −0.001 (−0.038; 0.036) | 0.954 |
 Apoptosis (N = 13) | 0.027 (−0.004; 0.059) | 0.087 | 0.018 (−0.016; 0.052) | 0.294 | 0.033 (−0.004; 0.069) | 0.077 |
 Membrane proteins (N = 12) | 0.057 (0.025; 0.088) | 3.88*10 −4 | 0.048 (0.015; 0.082) | 0.005 | 0.028 (−0.008; 0.065) | 0.124 |
 Hormone metabolism/regulation (N = 4) | −0.009 (−0.041; 0.022) | 0.564 | −0.009 (−0.042; 0.025) | 0.610 | 0.010 (−0.027; 0.046) | 0.604 |
 Purine/pyrimidine cycle (N = 4) | 0.009 (−0.022; 0.041) | 0.557 | 0.039 (0.006; 0.073) | 0.023 | −0.025 (−0.061; 0.011) | 0.178 |
 Monogenic obesity/energy homeostasis (N = 9) | −0.013 (−0.045; 0.018) | 0.406 | −0.014 (−0.048; 0.020) | 0.413 | 0.026 (−0.011; 0.062) | 0.168 |
 Immune system (N = 15) | 0.045 (0.014; 0.076) | 0.005 | 0.049 (0.015; 0.082) | 0.004 | −0.003 (−0.039; 0.033) | 0.868 |
 Limb development (N = 3) | 0.018 (−0.014; 0.049) | 0.267 | 0.022 (−0.011; 0.056) | 0.195 | 0.001 (−0.035; 0.037) | 0.945 |
 Ubiquitin pathways (N = 6) | −0.006 (−0.038; 0.025) | 0.684 | 0.007 (−0.027; 0.040) | 0.693 | −0.025 (−0.061; 0.011) | 0.168 |
 Glucose homeostasis/diabetes (N = 11) | 0.023 (−0.009; 0.054) | 0.160 | 0.021 (−0.013; 0.055) | 0.219 | 0.026 (−0.010; 0.063) | 0.156 |
 Cell cycle (N = 23) | 0.008 (−0.023; 0.039) | 0.611 | 0.011 (−0.023; 0.044) | 0.538 | −0.001 (−0.037; 0.035) | 0.959 |
DNARepair | ||||||
 Nuclear trafficking (N = 4) | −0.015 (−0.047; 0.017) | 0.362 | −0.023 (−0.057; 0.011) | 0.187 | −0.032 (−0.068; 0.005) | 0.092 |
 Muscle biology (N = 6) | −0.011 (−0.043; 0.020) | 0.479 | −0.0003 (−0.034; 0.033) | 0.985 | 0.014 (−0.022; 0.050) | 0.446 |