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Table 4 Associations of nine SNPs of the FASN gene with milk medium-chain fatty acids (MCFAs) in Chinese Holstein cattle (LSM ± SE)

From: Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study

Locus

Genotypes

C10:0

C12:0

C14:0

C14:1

  

rs136947640

CC(248)

2.13 ± 0.06

2.63 ± 0.08

9.55 ± 0.13

0.79 ± 0.03

  

TT(2)

2.23 ± 0.24

2.66 ± 0.32

8.92 ± 0.54

0.65 ± 0.16

  

CT(64)

2.09 ± 0.07

2.56 ± 0.09

9.42 ± 0.15

0.78 ± 0.04

  

P-value

0.6139

0.5290

0.2611

0.6836

  

rs41919999

CC(64)

2.13 ± 0.07AB

2.68 ± 0.09AB

9.64 ± 0.15A

0.76 ± 0.04

  

TT(88)

1.99 ± 0.07B

2.53 ± 0.09B

9.25 ± 0.14B

0.79 ± 0.04

  

CT(162)

2.15 ± 0.06A

2.73 ± 0.08A

9.52 ± 0.13A

0.80 ± 0.03

  

P-value

0.0012

0.0041

0.0071

0.6264

  

rs132865003

CC(220)

2.11 ± 0.06

2.68 ± 0.08

9.52 ± 0.13

0.80 ± 0.03

  

TT(10)

2.17 ± 0.12

2.72 ± 0.16

9.45 ± 0.26

0.75 ± 0.08

  

CT(85)

2.11 ± 0.06

2.68 ± 0.08

9.49 ± 0.14

0.78 ± 0.04

  

P-value

0.8601

0.9610

0.9217

0.7157

  

rs134340637

AA(10)

2.17 ± 0.12

2.72 ± 0.16

9.45 ± 0.26

0.75 ± 0.08

  

GG(220)

2.11 ± 0.06

2.68 ± 0.08

9.52 ± 0.13

0.80 ± 0.03

  

AG(85)

2.11 ± 0.06

2.68 ± 0.08

9.49 ± 0.14

0.78 ± 0.04

  

P-value

0.8601

0.9610

0.9217

0.7157

  

rs41919992

CC(157)

2.05 ± 0.06A

2.53 ± 0.08A

9.31 ± 0.13A

0.77 ± 0.04

  

TT(24)

2.06 ± 0.09AB

2.45 ± 0.12A

9.35 ± 0.20A

0.76 ± 0.06

  

CT(133)

2.20 ± 0.06B

2.74 ± 0.08B

9.75 ± 0.13B

0.79 ± 0.04

  

P-value

0.0013

<.0001

<.0001

0.6169

  

rs133498277

CC(157)

2.05 ± 0.06A

2.53 ± 0.08A

9.32 ± 0.13A

0.77 ± 0.04

  

TT(23)

2.07 ± 0.09AB

2.47 ± 0.12A

9.42 ± 0.20AB

0.75 ± 0.06

  

CT(134)

2.18 ± 0.06B

2.73 ± 0.08B

9.75 ± 0.13B

0.79 ± 0.04

  

P-value

0.0043

0.0003

<.0001

0.6826

  

rs41919984

CC(157)

2.06 ± 0.09AB

2.51 ± 0.11A

9.38 ± 0.19AB

0.76 ± 0.06

  

TT(24)

2.04 ± 0.06B

2.58 ± 0.08A

9.29 ± 0.13B

0.78 ± 0.04

  

TC(134)

2.19 ± 0.06A

2.81 ± 0.08B

9.74 ± 0.13A

0.80 ± 0.04

  

P-value

0.0010

<.0001

<.0001

0.6958

  

rs41919985

AA(25)

2.08 ± 0.09AB

2.54 ± 0.11A

9.46 ± 0.19AB

0.76 ± 0.06

  

GG(157)

2.04 ± 0.06B

2.58 ± 0.08A

9.28 ± 0.13B

0.78 ± 0.04

  

GA(133)

2.18 ± 0.06A

2.80 ± 0.08B

9.73 ± 0.13A

0.80 ± 0.04

  

P-value

0.0017

<.0001

<.0001

0.7268

  

rs41919986

CC(155)

2.03 ± 0.06A

2.54 ± 0.08A

9.36 ± 0.13A

0.77 ± 0.04

  

TT(25)

2.08 ± 0.09AB

2.50 ± 0.11A

9.50 ± 0.19AB

0.76 ± 0.06

  

CT(132)

2.17 ± 0.06B

2.74 ± 0.08B

9.78 ± 0.13B

0.79 ± 0.04

  

P-value

0.0015

0.0002

<.0001

0.7225

  

Locus

Genotypes

C16:0

C16:1

C18:0

C18:1n9c

C18:2n6c

CLA

rs136947640

CC(248)

32.30 ± 0.33

1.75 ± 0.05

12.59 ± 0.17

29.36 ± 0.22

4.03 ± 0.03A

0.38 ± 0.01

TT(2)

32.38 ± 1.52

1.86 ± 0.21

12.25 ± 0.85

30.18 ± 1.13

3.73 ± 0.13A

0.38 ± 0.05

CT(64)

32.17 ± 0.40

1.81 ± 0.06

12.54 ± 0.21

29.36 ± 0.28

4.12 ± 0.03B

0.40 ± 0.01

P-value

0.9155

0.3007

0.9028

0.7714

<.0001

0.3536

rs41919999

CC(64)

32.22 ± 0.40

1.79 ± 0.06

12.31 ± 0.21

29.43 ± 0.28

4.09 ± 0.03

0.40 ± 0.01

TT(88)

32.23 ± 0.38

1.77 ± 0.05

12.68 ± 0.20

29.82 ± 0.27

4.08 ± 0.03

0.38 ± 0.01

CT(162)

32.11 ± 0.34

1.76 ± 0.05

12.50 ± 0.17

29.36 ± 0.23

4.07 ± 0.03

0.39 ± 0.01

P-value

0.8921

0.7478

0.2182

0.0982

0.5542

0.4618

rs132865003

CC(220)

32.24 ± 0.33

1.75 ± 0.05

12.54 ± 0.17

29.44 ± 0.22

4.06 ± 0.03a

0.38 ± 0.01

TT(10)

32.65 ± 0.73

1.78 ± 0.10

12.43 ± 0.40

28.95 ± 0.54

4.00 ± 0.06ab

0.41 ± 0.02

CT(85)

32.19 ± 0.36

1.80 ± 0.05

12.46 ± 0.19

29.35 ± 0.25

4.12 ± 0.03b

0.40 ± 0.01

P-value

0.8073

0.4185

0.8504

0.6087

0.0128

0.1185

rs134340637

AA(10)

32.65 ± 0.73

1.78 ± 0.10

12.43 ± 0.40

28.95 ± 0.54

4.00 ± 0.06ab

0.41 ± 0.02

GG(220)

32.24 ± 0.33

1.75 ± 0.05

12.54 ± 0.17

29.44 ± 0.22

4.06 ± 0.03b

0.38 ± 0.01

AG(85)

32.19 ± 0.36

1.80 ± 0.05

12.46 ± 0.19

29.35 ± 0.25

4.12 ± 0.03a

0.40 ± 0.01

P-value

0.8073

0.4185

0.8504

0.6087

0.0128

0.1185

rs41919992

CC(157)

32.21 ± 0.35

1.79 ± 0.05

12.67 ± 0.18

29.68 ± 0.24A

4.05 ± 0.03

0.39 ± 0.01

TT(24)

31.62 ± 0.54

1.80 ± 0.08

12.69 ± 0.29

30.64 ± 0.39C

4.02 ± 0.04

0.38 ± 0.02

CT(133)

32.42 ± 0.35

1.73 ± 0.05

12.45 ± 0.18

28.89 ± 0.24B

4.05 ± 0.03

0.38 ± 0.01

P-value

0.2037

0.2115

0.2499

<.0001

0.8456

0.7406

rs133498277

CC(157)

32.22 ± 0.35

1.80 ± 0.05

12.67 ± 0.18

29.71 ± 0.24A

4.05 ± 0.03

0.39 ± 0.01

TT(23)

31.57 ± 0.54

1.82 ± 0.08

12.59 ± 0.29

30.62 ± 0.39C

4.06 ± 0.04

0.38 ± 0.02

CT(134)

32.44 ± 0.35

1.74 ± 0.05

12.47 ± 0.18

28.92 ± 0.24B

4.05 ± 0.03

0.38 ± 0.01

P-value

0.1847

0.2131

0.3740

<.0001

0.9503

0.8353

rs41919984

CC(157)

31.54 ± 0.53

1.79 ± 0.07

12.64 ± 0.29

30.68 ± 0.38A

4.06 ± 0.04

0.38 ± 0.02

TT(24)

32.16 ± 0.34

1.80 ± 0.05

12.62 ± 0.18

29.75 ± 0.24C

4.08 ± 0.03

0.39 ± 0.01

TC(134)

32.41 ± 0.34

1.73 ± 0.05

12.39 ± 0.17

28.88 ± 0.23B

4.08 ± 0.03

0.39 ± 0.01

P-value

0.1507

0.2088

0.2673

<.0001

0.8309

0.6460

rs41919985

AA(25)

31.55 ± 0.53

1.8 ± 0.07

12.52 ± 0.29

30.59 ± 0.38A

4.07 ± 0.04

0.38 ± 0.02

GG(157)

32.16 ± 0.34

1.80 ± 0.05

12.61 ± 0.18

29.75 ± 0.24A

4.08 ± 0.03

0.39 ± 0.01

GA(133)

32.41 ± 0.34

1.73 ± 0.05

12.41 ± 0.17

28.88 ± 0.23B

4.08 ± 0.03

0.39 ± 0.01

P-value

0.1446

0.1888

0.3716

<.0001

0.9818

0.6229

rs41919986

CC(155)

32.11 ± 0.34

1.80 ± 0.05

12.67 ± 0.18

29.77 ± 0.24A

4.05 ± 0.03

0.39 ± 0.01

TT(25)

31.53 ± 0.53

1.81 ± 0.07

12.54 ± 0.29

30.60 ± 0.38A

4.05 ± 0.04

0.38 ± 0.02

CT(132)

32.38 ± 0.35

1.74 ± 0.05

12.50 ± 0.18

28.88 ± 0.24B

4.03 ± 0.03

0.38 ± 0.01

P-value

0.1502

0.1425

0.4945

<.0001

0.7292

0.6757

Locus

Genotypes

C14INDEX

C16INDEX

C18INDEX

SFA

UFA

SFA/UFA

rs136947640

CC(248)

7.62 ± 0.26

5.15 ± 0.12

69.96 ± 0.52

61.45 ± 0.31

36.89 ± 0.28

1.70 ± 0.04

TT(2)

6.69 ± 1.19

5.44 ± 0.54

71.10 ± 2.50

60.67 ± 1.52

37.49 ± 1.39

1.62 ± 0.20

CT(64)

7.62 ± 0.31

5.35 ± 0.14

70.06 ± 0.63

61.09 ± 0.38

37.08 ± 0.34

1.68 ± 0.05

P-value

0.7344

0.1582

0.8863

0.4488

0.7360

0.8360

rs41919999

CC(64)

7.39 ± 0.31

5.27 ± 0.14

70.57 ± 0.63

61.22 ± 0.38

37.11 ± 0.35

1.67 ± 0.05

TT(88)

7.84 ± 0.30

5.22 ± 0.14

70.18 ± 0.60

60.92 ± 0.36

37.43 ± 0.33

1.66 ± 0.05

CT(162)

7.73 ± 0.26

5.20 ± 0.12

70.13 ± 0.53

61.29 ± 0.31

36.96 ± 0.29

1.69 ± 0.04

P-value

0.2796

0.8450

0.7036

0.4242

0.2017

0.7246

rs132865003

CC(220)

7.74 ± 0.26

5.16 ± 0.12

70.10 ± 0.51

61.31 ± 0.31

37.02 ± 0.28

1.69 ± 0.04

TT(10)

7.36 ± 0.57

5.17 ± 0.26

70.04 ± 1.19

61.77 ± 0.72

36.54 ± 0.66

1.71 ± 0.10

CT(85)

7.60 ± 0.28

5.30 ± 0.13

70.22 ± 0.57

61.17 ± 0.34

37.06 ± 0.31

1.68 ± 0.05

P-value

0.6364

0.2951

0.9567

0.6591

0.7296

0.9378

rs134340637

AA(10)

7.36 ± 0.57

5.17 ± 0.26

70.04 ± 1.19

61.77 ± 0.72

36.54 ± 0.66

1.71 ± 0.10

GG(220)

7.74 ± 0.26

5.16 ± 0.12

70.10 ± 0.51

61.31 ± 0.31

37.02 ± 0.28

1.69 ± 0.04

AG(85)

7.60 ± 0.28

5.30 ± 0.13

70.22 ± 0.57

61.17 ± 0.34

37.06 ± 0.31

1.68 ± 0.05

P-value

0.6364

0.2951

0.9567

0.6591

0.7296

0.9378

rs41919992

CC(157)

7.66 ± 0.27

5.30 ± 0.12a

70.06 ± 0.55

61.03 ± 0.33A

37.27 ± 0.30A

1.67 ± 0.04

TT(24)

7.50 ± 0.42

5.40 ± 0.19ab

70.71 ± 0.87

60.33 ± 0.52A

38.22 ± 0.48A

1.60 ± 0.07

CT(133)

7.56 ± 0.28

5.08 ± 0.13b

69.86 ± 0.55

61.82 ± 0.33B

36.44 ± 0.30B

1.72 ± 0.04

P-value

0.8491

0.0190

0.5297

0.0004

<.0001

0.0612

rs133498277

CC(157)

7.58 ± 0.27

5.31 ± 0.12a

70.07 ± 0.54

61.05 ± 0.32A

37.31 ± 0.29A

1.67 ± 0.04

TT(23)

7.42 ± 0.42

5.45 ± 0.19a

70.84 ± 0.87

60.29 ± 0.53A

38.25 ± 0.48A

1.60 ± 0.07

CT(134)

7.48 ± 0.27

5.10 ± 0.12b

69.81 ± 0.54

61.84 ± 0.32B

36.46 ± 0.30B

1.73 ± 0.04

P-value

0.8410

0.0178

0.4115

0.0004

<.0001

0.0617

rs41919984

CC(157)

7.53 ± 0.42

5.37 ± 0.19ab

70.82 ± 0.86

60.27 ± 0.52A

38.29 ± 0.47A

1.60 ± 0.07a

TT(24)

7.77 ± 0.27

5.32 ± 0.12b

70.24 ± 0.54

60.91 ± 0.32A

37.40 ± 0.29A

1.66 ± 0.04ab

TC(134)

7.61 ± 0.27

5.08 ± 0.12a

69.95 ± 0.53

61.77 ± 0.32B

36.48 ± 0.29B

1.72 ± 0.04b

P-value

0.6745

0.0154

0.4795

0.0002

<.0001

0.0450

rs41919985

AA(25)

7.51 ± 0.41

5.38 ± 0.19ab

70.97 ± 0.85

60.31 ± 0.51A

38.23 ± 0.47A

1.60 ± 0.07a

GG(157)

7.77 ± 0.27

5.32 ± 0.12b

70.24 ± 0.54

60.91 ± 0.32A

37.4 ± 0.29A

1.66 ± 0.04ab

GA(133)

7.61 ± 0.27

5.07 ± 0.12a

69.93 ± 0.53

61.77 ± 0.32B

36.47 ± 0.29B

1.72 ± 0.04b

P-value

0.6642

0.0122

0.3517

0.0002

<.0001

0.0472

rs41919986

CC(155)

7.61 ± 0.27

5.34 ± 0.12A

70.09 ± 0.54

60.97 ± 0.32A

37.37 ± 0.29A

1.66 ± 0.04ab

TT(25)

7.43 ± 0.41

5.45 ± 0.19A

70.92 ± 0.85

60.33 ± 0.51A

38.22 ± 0.47A

1.60 ± 0.07b

CT(132)

7.49 ± 0.27

5.09 ± 0.12B

69.71 ± 0.54

61.86 ± 0.32B

36.41 ± 0.29B

1.73 ± 0.04a

P-value

0.7937

0.0074

0.2439

0.0001

<.0001

0.0393

  1. Notes: P-value refers to the results of the association analysis between each SNP and milk fatty acid traits. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts (adjusted value after correction for multiple testing) indicate significant differences among the genotypes