The genetic variants in 3’ untranslated region of voltage-gated sodium channel alpha 1 subunit gene affect the mRNA-microRNA interactions and associate with epilepsy

Li, Tian; Kuang, Yaoyun; Li, Bin

doi:10.1186/s12863-016-0417-y

Table 3 The mean ± SD (standard deviation) of STarmir parameters in 11 genotype groups

From: The genetic variants in 3’ untranslated region of voltage-gated sodium channel alpha 1 subunit gene affect the mRNA-microRNA interactions and associate with epilepsy

	LogitProb	ΔGhybrid	ΔGnucl	ΔGtotal	site_access	Upstream_Access_10nt_nonconserved	Dwstream_Access_30nt_nonconserved	Upstream_AU_30nt	Dwstream_AU_30nt	Site_Location	Seed_Access	Upstream_Access_15nt_conserved	Dwstream_Access_10nt_conserved
Wild type	0.632 ± 0.079	−17.378 ± 2.116	−1.866 ± 1.802	−4.143 ± 4.935	0.406 ± 0.117	0.407 ± 0.163	0.426 ± 0.099	0.663 ± 0.116	0.670 ± 0.101	0.457 ± 0.289	0.385 ± 0.169	0.419 ± 0.113	0.382 ± 0.122
CTTTA	0.626 ± 0.079	−17.397 ± 2.129	−1.789 ± 1.774	−3.757 ± 5.011	0.396 ± 0.117	0.411 ± 0.166	0.427 ± 0.103	0.661 ± 0.116	0.669 ± 0.102	0.450 ± 0.288	0.350 ± 0.165	0.462 ± 0.162	0.393 ± 0.142
CTCTA	0.633 ± 0.081	−17.371 ± 2.107	−1.870 ± 1.894	−4.172 ± 5.175	0.408 ± 0.128	0.412 ± 0.175	0.431 ± 0.107	0.660 ± 0.116	0.669 ± 0.102	0.448 ± 0.287	0.369 ± 0.191	0.445 ± 0.148	0.383 ± 0.137
CCTTA	0.625 ± 0.079	−17.409 ± 2.135	−1.829 ± 1.719	−3.815 ± 4.867	0.396 ± 0.110	0.405 ± 0.155	0.422 ± 0.096	0.662 ± 0.116	0.669 ± 0.102	0.458 ± 0.289	0.359 ± 0.165	0.448 ± 0.130	0.387 ± 0.135
TTTTA	0.627 ± 0.079	−17.400 ± 2.124	−1.824 ± 1.790	−3.814 ± 5.027	0.394 ± 0.119	0.408 ± 0.166	0.426 ± 0.107	0.662 ± 0.116	0.669 ± 0.102	0.453 ± 0.289	0.335 ± 0.169	0.458 ± 0.149	0.392 ± 0.131
CTTAACA	0.626 ± 0.078	−17.407 ± 2.135	−1.823 ± 1.711	−3.841 ± 4.851	0.397 ± 0.110	0.406 ± 0.155	0.422 ± 0.096	0.663 ± 0.116	0.669 ± 0.102	0.459 ± 0.290	0.362 ± 0.137	0.446 ± 0.125	0.393 ± 0.122
TTCAACA	0.626 ± 0.080	−17.394 ± 2.126	−1.824 ± 1.782	−3.839 ± 5.007	0.398 ± 0.120	0.410 ± 0.167	0.428 ± 0.104	0.659 ± 0.117	0.668 ± 0.102	0.450 ± 0.287	0.346 ± 0.156	0.459 ± 0.142	0.392 ± 0.131
TTTAACA	0.625 ± 0.078	−17.397 ± 2.129	−1.782 ± 1.752	−3.724 ± 4.940	0.394 ± 0.115	0.410 ± 0.166	0.428 ± 0.103	0.661 ± 0.116	0.668 ± 0.102	0.450 ± 0.287	0.357 ± 0.167	0.461 ± 0.157	0.396 ± 0.138
6568_6571del	0.628 ± 0.078	−17.401 ± 2.130	−1.841 ± 1.788	−3.910 ± 4.956	0.398 ± 0.116	0.408 ± 0.162	0.418 ± 0.099	0.663 ± 0.116	0.668 ± 0.103	0.460 ± 0.290	0.347 ± 0.147	0.433 ± 0.132	0.376 ± 0.135
7338_7344del	0.627 ± 0.079	−17.408 ± 2.131	−1.844 ± 1.681	−3.969 ± 4.686	0.397 ± 0.106	0.406 ± 0.149	0.421 ± 0.095	0.663 ± 0.116	0.669 ± 0.103	0.459 ± 0.290	0.369 ± 0.127	0.457 ± 0.119	0.393 ± 0.109
7065_7066insG	0.629 ± 0.079	−17.394 ± 2.124	−1.843 ± 1.741	−4.048 ± 4.858	0.402 ± 0.112	0.406 ± 0.158	0.423 ± 0.097	0.662 ± 0.116	0.669 ± 0.102	0.458 ± 0.290	0.373 ± 0.164	0.431 ± 0.125	0.382 ± 0.127

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