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Fig. 3 | BMC Genetics

Fig. 3

From: Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers

Fig. 3

Transmission of trisomy reduces with maternal age in Ts65Dn model mice. a Probability of a trisomic pup for females younger than 200 days (n = 73) and for females older than 200 days (n = 4, p = 0.52). The analysis was performed only for litters where the genotype for the entire progeny is known. b Probability of a trisomic pup for females younger than 200 days (n = 101) is ~ 3 fold higher than for females older than 200 days (n = 11, p = 0.0029). The analysis was performed for the entire dataset. For some of the dataset only female information exists (see Methods)

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