TY - JOUR AU - Stern, Shani AU - Biron, David AU - Moses, Elisha PY - 2016 DA - 2016/07/11 TI - Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothers JO - BMC Genetics SP - 105 VL - 17 IS - 1 AB - Down syndrome incidence in humans increases dramatically with maternal age. This is mainly the result of increased meiotic errors, but factors such as differences in abortion rate may play a role as well. Since the meiotic error rate increases almost exponentially after a certain age, its contribution to the overall incidence aneuploidy may mask the contribution of other processes. SN - 1471-2156 UR - https://doi.org/10.1186/s12863-016-0412-3 DO - 10.1186/s12863-016-0412-3 ID - Stern2016 ER -