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Table 6 Estimated power and LOD score threshold based on 10,000 simulation replicates for F2 intercross between CSS-19A and CSS-19PWDa

From: Consomic mouse strain selection based on effect size measurement, statistical significance testing and integrated behavioral z-scoring: focus on anxiety-related behavior and locomotion

Number of male F2 animals (LOD threshold)b

Genotype datac

Position of additive QTL(s): at length of MMU19 (≈ cM)

Power

¼ (≈14.6)

½ (≈29.2)

¾ (≈43.7)

Markers (24) equally spaced

Randomly positioned markers (24)

Average spacing = 2.5 cM

Average spacing = 2.5 cM

Maximum spacing = 2.5 cM

Maximum spacing = 7.5 cM

N = 33

Error-free / complete

+

–

–

0.5489

0.5593

(2.4520)

1 % G / 5 % M

+

–

–

0.5613

0.5574

 

Error-free / complete

–

+

–

0.5528

0.5657

 

1 % G / 5 % M

–

+

–

0.5695

0.5422

 

Error-free /complete

–

–

+

0.5453

0.5585

 

1 % G / 5 % M

–

–

+

0.5663

0.5438

 

Error-free /complete

+

+

–

0.3129

0.3227

 

1 % G / 5 % M

+

+

–

0.3363

0.3142

 

Error-free / complete

+

–

+

0.3027

0.2993

 

1 % G / 5 % M

+

–

+

0.3087

0.3003

 

Error-free / complete

–

+

+

0.3296

0.3303

 

1 % G / 5 % M

–

+

+

0.3454

0.3078

N = 66

Error-free / complete

+

–

–

0.9122

0.9102

(2.3497)

1 % G / 5 % M

+

–

–

0.9118

0.8958

 

Error-free / complete

–

+

–

0.9078

0.9100

 

1 % G / 5 % M

–

+

–

0.9128

0.8838

 

Error-free / complete

–

–

+

0.9086

0.9128

 

1 % G / 5 % M

–

–

+

0.9152

0.8920

 

Error-free / complete

+

+

–

0.6511

0.6513

 

1 % G / 5 % M

+

+

–

0.6556

0.6097

 

Error-free / complete

+

–

+

0.5973

0.5823

 

1 % G / 5 % M

+

–

+

0.6076

0.5513

 

Error-free / complete

–

+

+

0.6516

0.6410

 

1 % G / 5 % M

–

+

+

0.6599

0.6025

N = 99

Error-free / complete

+

–

–

0.9885

0.9891

(2.3321)

1 % G / 5 % M

+

–

–

0.9898

0.9874

 

Error-free / complete

–

+

–

0.9871

0.9867

 

1 % G / 5 % M

–

+

–

0.9878

0.9867

 

Error-free / complete

–

–

+

0.9898

0.9873

 

1 % G / 5 % M

–

–

+

0.9887

0.9892

 

Error-free / complete

+

+

–

0.8551

0.8351

 

1 % G / 5 % M

+

+

–

0.8511

0.8434

 

Error-free / complete

+

–

+

0.7865

0.7878

 

1 % G / 5 % M

+

–

+

0.7958

0.7938

 

Error-free / complete

–

+

+

0.8427

0.8402

 

1 % G / 5 % M

–

+

+

0.8564

0.8456

N = 132

Error-free / complete

+

–

–

0.9989

0.9987

(2.3086)

1 % G / 5 % M

+

–

–

0.9990

0.9983

 

Error-free / complete

–

+

–

0.9988

0.9988

 

1 % G / 5 % M

–

+

–

0.9990

0.9986

 

Error-free / complete

–

–

+

0.9993

0.9982

 

1 % G / 5 % M

–

–

+

0.9990

0.9993

 

Error-free / complete

+

+

–

0.9466

0.9413

 

1 % G / 5 % M

+

+

–

0.9447

0.9446

 

Error-free / complete

+

–

+

0.9118

0.9057

 

1 % G / 5 % M

+

–

+

0.9110

0.9069

 

Error-free

–

+

+

0.9427

0.9423

 

1 % G / 5 % M

–

+

+

0.9479

0.9399

  1. a The genetic length of male mouse chromosome 19 is 58.309 cM [49]
  2. b Estimate of the 5 % LOD threshold
  3. c ‘1 % G / 5 % M’ means 1 % genotyping errors and 5 % missing data
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BMC Genomic Data

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