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Table 3 Amounts of HFE haplotypes and their frequencies for rs2071303, rs1800708, rs1572982, C282Y, H63D, and S65C in various populations, groups of patients, and long-lived people

From: Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people

Groups

TTG WT

TTG C282Y

CTA WT

CTA H63D

TTA

CCA WT

CCA S65C

Populations

Russian adolescents

331

16

75

118

103

59

10

0.46

0.02

0.11

0.17

0.14

0.08

0.01

Russian old believers (an isolate)

101

7

18

21

33

20

4

0.5

0.03

0.09

0.1

0.16

0.1

0.02

Germans, Altai

79a

4

26

29

13

5

4

0.49

0.03

0.16

0.18

0.08

0.03

0.03

Siberian Tatars

207

0

34

21

56

71

7

0.52

0.09

0.05

0.14

0.18

0.02

Shorians

107a

1

26

20

44

81

5

0.38

0.004

0.09

0.07

0.15

0.29

0.02

Khakas

67

1

13a

9

33

43

4

0.39

0.006

0.08

0.05

0.19

0.26

0.02

Yukaghirs

71

5

8

7

14

55

2

0.44

0.03

0.05

0.04

0.09

0.34

0.01

Yakuts

32

0

1

1

11

17

0

0.52

0.02

0.02

0.18

0.27

Nivkhs

15

0

1

3

4

35

0

0.26

0.02

0.05

0.07

0.6

Koryaks

53

0

12

3

8

86a

0

0.33

0.07

0.02

0.05

0.53

Evenks

30

0

3

2

4

37

0

0.39

0.04

0.03

0.05

0.49

Nanaians

23

0

14

5

1

23

0

0.35

0.21

0.08

0.02

0.35

Eskimos

29

0

4

0

17

34

0

0.35

0.05

0.2

0.4

Patients, Novosibirsk

MS + AG total

387

21

66

84

105

68

9

0.52

0.03

0.09

0.11

0.14

0.09

0.01

MS + AH, women

243

12

36

54

77

48

2

0.51

0.03

0.08

0.11

0.16

0.1

0.004

MS + AH, men

144

9

30

28

28

20

7

0.54

0.03

0.11

0.11

0.11

0.08

0.03

Fatty liver disease

78

6

15

17

17

10

5

0.53

0.04

0.1

0.11

0.11

0.07

0.03

T2DM

172

6

32

46

28

20

6

0.55

0.02

0.1

0.15

0.09

0.06

0.02

Stomach cancer

154

6

38

40

38

22

2

0.51

0.02

0.13

0.13

0.13

0.07

0.01

Long-lived people

total

270

9

47

63

66

51

2

0.53

0.02

0.09

0.12

0.13

0.1

0.004

men

57

2

9

13

19

8

0

0.53

0.02

0.08

0.11

0.18

0.07

women

213

7

38

50

47

43

2

0.53

0.02

0.1

0.13

0.12

0.11

0.005

  1. WT are gene variants without the exonic SNPs; MS + AH: metabolic syndrome associated with arterial hypertension, T2DM: type 2 diabetes mellitus, adeviations from Hardy-Weinberg equilibrium