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Table 6 BMI-associated SNPs in ERBB4 in MESA and WHI African Americans

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

 

MESA African Americans

WHI African Americans

SNP

Bp

Minor Allele

Model

beta (95 % CI)

p

beta (95 % CI)

p

rs6435678

212,418,713

C

Unadjusted

1.106 (0.647, 1.565)

2.58 × 10−06

0.350 (0.098, 0.602)

0.006

+ PC 1 and 2

1.012 (0.526, 1.498)

4.71 × 10−05

0.238 (−0.014, 0.489)

0.064

+ age and sexa

1.121 (0.652, 1.591)

3.10 × 10−06

0.249 (−0.001, 0.500)

0.051

Full modela,b

1.104 (0.643, 1.564)

2.85 × 10−06

0.232 (−0.009, 0.476)

0.061

rs16847102

212,431,233

A

Unadjusted

0.938 (0.458, 1.418)

1.33 × 10−04

0.349 (0.100, 0.599)

0.006

+ PC 1 and 2

0.911 (0.430, 1.393)

2.15 × 10−04

0.238 (−0.012, 0.487)

0.062

+ age and sexa

1.041 (0.576, 1.506)

1.25 × 10−05

0.245 (−0.003, 0.493)

0.053

Full modela,b

1.026 (0.570,1.483)

1.12 × 10−05

0.219 (−0.021, 0.460)

0.074

  1. Abbreviations: Bp base pair, CI Confidence Interval, PC principal components
  2. a Only the MESA analyses are sex-adjusted
  3. b Full model includes all ethnic-specific model covariates