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Table 5 BMI-associated SNPs in TCF7L2 in MESA and WHI Hispanics

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

  MESA Hispanics WHI Hispanics
  Full modela Full modela w/o diabetes Full Modela Full modela w/o diabetes
SNP Bp Minor Allele beta (95 % CI) p beta (95 % CI) p beta (95 % CI) p beta (95 % CI) p
rs7901695 114,744,078 C −0.867 (−1.291, −0.442) 6.60 × 10−05 −0.812 (−1.244, −0.380) 2.41 × 10−04 −0.403 (−0.690, −0.116) 0.006 −0.381 (−0.669, −0.092) 0.010
rs4506565 114,746,031 A −0.885 (−1.310, −0.460) 4.81 × 10−05 −0.835 (−1.267, −0.402) 1.64 × 10−04 −0.415 (−0.703, −0.128) 0.005 −0.396 (−0.686, −0.107) 0.007
rs4132670 114,757,761 A −0.816 (−1.256, −0.377) 2.86 × 10−04 −0.793 (−1.241, −0.345) 0.001 −0.337 (−0.628, −0.047) 0.023 −0.321 (−0.614, −0.028) 0.032
rs12243326 114,778,805 G −0.990 (−1.457, −0.523) 3.46 × 10−05 −0.991 (−1.467, −0.515) 4.72 × 10−05 −0.251 (−0.560, 0.059) 0.112 −0.243 (−0.554, 0.069) 0.127
rs12255372 114,798,892 T −1.111 (−1.578, −0.645) 3.33 × 10−06 −1.103 (−1.578, −0.628) 5.82 × 10−06 −0.304 (−0.613, 0.006) 0.054 −0.296 (−0.608, 0.015) 0.063
  1. Abbreviations Bp = base pair, CI = Confidence Interval; w/o = without
  2. a Full model includes: PC1 and PC2, age, sex, and ethnic-specific model covariates; only MESA analyses are sex-adjusted