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Table 5 BMI-associated SNPs in TCF7L2 in MESA and WHI Hispanics

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

 

MESA Hispanics

WHI Hispanics

 

Full modela

Full modela w/o diabetes

Full Modela

Full modela w/o diabetes

SNP

Bp

Minor Allele

beta (95 % CI)

p

beta (95 % CI)

p

beta (95 % CI)

p

beta (95 % CI)

p

rs7901695

114,744,078

C

−0.867 (−1.291, −0.442)

6.60 × 10−05

−0.812 (−1.244, −0.380)

2.41 × 10−04

−0.403 (−0.690, −0.116)

0.006

−0.381 (−0.669, −0.092)

0.010

rs4506565

114,746,031

A

−0.885 (−1.310, −0.460)

4.81 × 10−05

−0.835 (−1.267, −0.402)

1.64 × 10−04

−0.415 (−0.703, −0.128)

0.005

−0.396 (−0.686, −0.107)

0.007

rs4132670

114,757,761

A

−0.816 (−1.256, −0.377)

2.86 × 10−04

−0.793 (−1.241, −0.345)

0.001

−0.337 (−0.628, −0.047)

0.023

−0.321 (−0.614, −0.028)

0.032

rs12243326

114,778,805

G

−0.990 (−1.457, −0.523)

3.46 × 10−05

−0.991 (−1.467, −0.515)

4.72 × 10−05

−0.251 (−0.560, 0.059)

0.112

−0.243 (−0.554, 0.069)

0.127

rs12255372

114,798,892

T

−1.111 (−1.578, −0.645)

3.33 × 10−06

−1.103 (−1.578, −0.628)

5.82 × 10−06

−0.304 (−0.613, 0.006)

0.054

−0.296 (−0.608, 0.015)

0.063

  1. Abbreviations Bp = base pair, CI = Confidence Interval; w/o = without
  2. a Full model includes: PC1 and PC2, age, sex, and ethnic-specific model covariates; only MESA analyses are sex-adjusted