Regional plot for rs12255372 and flanking region (±500 kb) markers in MESA and WHI Hispanics. The associations between BMI and markers (that met our QC metrics) in this region were assessed using linear regression in PLINK. p-values shown were adjusted for the following covariates in MESA and WHI: age, sex, smoking, diabetes, and arthritis. Only MESA analyses were sex-adjusted. Associations were evaluated against a Bonferroni-corrected significance threshold of 5.86 × 10−8 in MESA and against a nominal significance threshold of 0.05 in WHI. BMI-associated variants in both populations lie in the intronic region of TCF7L2. The blue arrow along the horizontal axis denotes the gene position and direction of transcription.