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Fig. 1 | BMC Genetics

Fig. 1

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

Fig. 1

Regional plot for rs12255372 and flanking region (±500 kb) markers in MESA and WHI Hispanics. The associations between BMI and markers (that met our QC metrics) in this region were assessed using linear regression in PLINK. p-values shown were adjusted for the following covariates in MESA and WHI: age, sex, smoking, diabetes, and arthritis. Only MESA analyses were sex-adjusted. Associations were evaluated against a Bonferroni-corrected significance threshold of 5.86 × 10−8 in MESA and against a nominal significance threshold of 0.05 in WHI. BMI-associated variants in both populations lie in the intronic region of TCF7L2. The blue arrow along the horizontal axis denotes the gene position and direction of transcription.

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BMC Genomic Data

ISSN: 2730-6844

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