Mutational and clinical analysis of the ENG gene in patients with pulmonary arterial hypertension

BMC Genomic Data

Table 2 Clinical features and hemodynamic parameters of patients

Clinical features and hemodynamic parameters	Total patients	Carriers of pathogenic mutations^a		Carriers of p.G191N mutation^b
Clinical features and hemodynamic parameters	Total patients	Clinical data	p-value	Clinical data	p-value
Number	57	16	----------	10	----------
Gender	21 M/36 F	6 M/10 F	n.s	2 M/8 F	n.s
Age at diagnosis (years)	49 ± 15	41 ± 16	0.040	39 ± 18	0.035
mPaP (mmHg)	49 ± 14	48 ± 11	n.s	45 ± 12	n.s
sPaP (mmHg)	70 ± 19	75 ± 16	n.s	67 ± 18	n.s
PVR (mmHg.l⁻¹.m⁻¹)	8.2 ± 3.5	8.6 ± 3.2	n.s	8.3 ± 0.9	n.s
CI (l.m⁻¹.m⁻²)	2.6 ± 0.6	2.5 ± 0.7	n.s	2.1 ± 0.5	0.049
6MWT (m)	445 ± 139	323 ± 162	0.040	457 ± 172	n.s
PAH types	29 IPAH/28 APAH	7 IPAH/9 APAH	n.s	8 IPAH/2 APAH	0.040

Values are expressed as the mean ± standard deviation; F female, M male, mPaP mean pulmonary artery pressure, sPaP systolic pulmonary artery pressure, PVR pulmonary vascular resistance, CI cardiac index, 6MWT 6 min walking test, IPAH idiopathic pulmonary arterial hypertension, APAH associated pulmonary arterial hypertension
^aWe have compared clinical features and hemodynamic parameters between patients with mutations in ENG gene and patients without mutations
^bWe have compared clinical features and hemodynamic parameters between patients with p.G191N variation in ENG gene and patients without mutations

ISSN: 2730-6844