Fig. 3

Ultrastructure of the glomeruli at 16 weeks of age. In ICGN mice (a), high-level effacement of the podocyte foot processes, high-level thickening of the GBM and swelling of the podocytes (Pod) were observed. In ICGN-Chr 2^B6 mice (b), normal GBM and foot processes (arrow) as well as thickening of the GBM (asterisk) and effacement of the foot processes (arrowhead) were observed with a much milder phenotype than that of ICGN mice. In ICGN-Tns2 ^WT mice (c), the glomeruli were nearly normal, but some part of the foot processes and the GBM was abnormal. Cap, capillary