Table 1 Sub-studies included from the GABRIEL Consortium
From: Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma
Study component | Sub-study | Reference | Country of origin | Case definition | Control definition | N, cases | N, controls |
|---|---|---|---|---|---|---|---|
Screening | GABRIEL-AS | [28] | Austria, Germany, Switzerland | Ever had doctor-diagnosed asthma or had asthmatic bronchitis at least twice (self-report). | Did not ever have doctor-diagnosed asthma and no asthmatic bronchitis diagnosed at least twice (self-report). | 802 | 823 |
Follow-up | BAMSE | [30] | Sweden | Ever had doctor-diagnosed asthma (self-report). | Did not have a history of asthma or other allergic diseases (self-report). | 226 | 235 |
BUSSELTON | [31] | Australia | Ever had doctor-diagnosed asthma (self-report). | Did not ever have doctor-diagnosed asthma (self-report). | 520 | 685 | |
EGEA | [32] | France | Ever had asthma attacks (self-report). | Did not ever have asthma attacks (self-report). | 120 | 444 | |
KMSU | [33] | Russia | Asthma diagnosed on the basis of symptoms (recurrent cough, wheezing, or dyspnea), airway obstruction reversibility, or airway methacholine hyper-responsiveness. | No symptoms or history of allergic disease, normal total serum IgE, normal pulmonary function. | 285 | 261 | |
PIAMA | [34] | The Netherlands | Ever had doctor-diagnosed asthma (self-report). | Did not have a history of asthma or other allergic diseases (self-report). | 174 | 187 | |
SAPALDIA | [35] | Switzerland | Ever had asthma (self-report). | Did not ever have asthma (self-report). | 581 | 880 | |
UFA | N/A | Russia | Asthma diagnosed on the basis of clinical examination, family and medication history, and lung function tests. | No symptoms or history of asthma or other pulmonary disease, no symptoms or history of atopy, no first-degree relatives with a history of asthma or atopy. | 333 | 333 | |
Sub-total (Follow-up) | 2239 | 3025 | |||||
Replication | AUGOSA | [36] | United Kingdom | Severe asthma (determined based on clinical assessments and control of symptoms) | N/A | 625 | 0 |
KARELIA | [37] | Finland, Russia | Ever had doctor-diagnosed asthma (self-report). | Did not ever have doctor-diagnosed asthma (self-report). | 57 | 68 | |
MAS | [38] | Germany | Ever had doctor-diagnosed asthma. | N/A | 173 | 0 | |
SEVERE | [39] | United Kingdom | Severe asthma (determined based on clinical assessments and control of symptoms) | N/A | 290 | 0 | |
Sub-total (Replication) | 1145 | 68 | |||||
Total (all) | 4186 | 3916 | |||||