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Table 6 Results of genetic associated analysis for pre-treatment pain in 1368 head and neck cancer patients (206 severe pain cases and 1162 non-severe pain controls), using the hubs (most interconnected molecules) obtained from IPA core analysis as the candidate molecules. The IPA symbol represents either a gene or a group of genes. The p value represents the most significant p value within a gene or a gene group. The molecules in boldface are focus genes

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

IPA symbol Location Family # of SNPs Genes Chr rs# OR P value
TNF Extracellular space Cytokine 3 TNF 6 rs1800630 1.20 1.78E-01
IFNG Extracellular space Cytokine 2 IFNG 12 rs2069727 0.84 8.85E-02
IL1B Extracellular space Cytokine 4 IL1B 2 rs16944 0.77 3.79E-02
CXCL8 Extracellular space Cytokine 1 CXCL8 4 rs2227543 1.09 3.78E-01
IL6 Extracellular space Cytokine 7 IL6 7 rs2069835 1.45 8.21E-02
Lh Plasma membrane Complex 5 CGA 6 rs9359730 1.26 3.48E-02
FSH Plasma membrane Complex 4 CGA 6 rs9359730 1.26 3.48E-02
NFkB (complex) Nucleus Complex 22 NFKB2 10 rs7897947 1.29 6.78E-02
IL10 Extracellular space Cytokine 4 IL10 1 rs3021094 1.11 6.08E-01
P38 MAPK Cytoplasm Group 33 MAPK1 22 rs8136867 1.33 8.92E-04
ERK1/2 Cytoplasm Group 13 MAPK1 22 rs8136867 1.33 8.92E-04
PTGS2 Cytoplasm Enzyme 3 PTGS2 1 rs5275 1.23 5.35E-02
IL4 Extracellular space Cytokine 5 IL4 5 rs2243248 0.81 3.19E-01
IL1RN Extracellular space Cytokine 12 IL1RN 2 rs17042917 0.77 1.43E-01
CD3 Plasma membrane Complex 44 CD247 1 rs2995082 0.76 7.79E-03
Vegf Extracellular space Group 47 PDGFC 4 rs6845322 1.32 4.88E-03
IL13 Extracellular space Cytokine 5 IL13 5 rs1881457 0.84 2.44E-01
PI3K (complex) Cytoplasm Complex 196 PIK3C2G 12 rs10770367 1.46 1.10E-03
IL12 (complex) Extracellular space Complex 10 IL12B 5 rs730691 0.77 1.68E-02
NFKB1 Nucleus Transcription regulator 9 NFKB1 4 rs1609798 1.20 9.42E-02
TCR Plasma membrane Complex 378 TCRA 14 rs6572493 0.70 2.84E-03
Akt Cytoplasm Group 33 AKT2 19 rs892120 1.35 3.15E-02
Fcer1 Plasma membrane Complex 15 FCER1G 1 rs11587213 0.68 1.68E-02
Cg Other Complex 8 CGA 6 rs9359730 1.26 3.48E-02
Interferon alpha Extracellular space Group 14 IFNA7 9 rs4977686 1.20 7.51E-02
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