Table 6 Results of genetic associated analysis for pre-treatment pain in 1368 head and neck cancer patients (206 severe pain cases and 1162 non-severe pain controls), using the hubs (most interconnected molecules) obtained from IPA core analysis as the candidate molecules. The IPA symbol represents either a gene or a group of genes. The p value represents the most significant p value within a gene or a gene group. The molecules in boldface are focus genes
From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients
IPA symbol | Location | Family | # of SNPs | Genes | Chr | rs# | OR | P value |
|---|---|---|---|---|---|---|---|---|
TNF | Extracellular space | Cytokine | 3 | TNF | 6 | rs1800630 | 1.20 | 1.78E-01 |
IFNG | Extracellular space | Cytokine | 2 | IFNG | 12 | rs2069727 | 0.84 | 8.85E-02 |
IL1B | Extracellular space | Cytokine | 4 | IL1B | 2 | rs16944 | 0.77 | 3.79E-02 |
CXCL8 | Extracellular space | Cytokine | 1 | CXCL8 | 4 | rs2227543 | 1.09 | 3.78E-01 |
IL6 | Extracellular space | Cytokine | 7 | IL6 | 7 | rs2069835 | 1.45 | 8.21E-02 |
Lh | Plasma membrane | Complex | 5 | CGA | 6 | rs9359730 | 1.26 | 3.48E-02 |
FSH | Plasma membrane | Complex | 4 | CGA | 6 | rs9359730 | 1.26 | 3.48E-02 |
NFkB (complex) | Nucleus | Complex | 22 | NFKB2 | 10 | rs7897947 | 1.29 | 6.78E-02 |
IL10 | Extracellular space | Cytokine | 4 | IL10 | 1 | rs3021094 | 1.11 | 6.08E-01 |
P38 MAPK | Cytoplasm | Group | 33 | MAPK1 | 22 | rs8136867 | 1.33 | 8.92E-04 |
ERK1/2 | Cytoplasm | Group | 13 | MAPK1 | 22 | rs8136867 | 1.33 | 8.92E-04 |
PTGS2 | Cytoplasm | Enzyme | 3 | PTGS2 | 1 | rs5275 | 1.23 | 5.35E-02 |
IL4 | Extracellular space | Cytokine | 5 | IL4 | 5 | rs2243248 | 0.81 | 3.19E-01 |
IL1RN | Extracellular space | Cytokine | 12 | IL1RN | 2 | rs17042917 | 0.77 | 1.43E-01 |
CD3 | Plasma membrane | Complex | 44 | CD247 | 1 | rs2995082 | 0.76 | 7.79E-03 |
Vegf | Extracellular space | Group | 47 | PDGFC | 4 | rs6845322 | 1.32 | 4.88E-03 |
IL13 | Extracellular space | Cytokine | 5 | IL13 | 5 | rs1881457 | 0.84 | 2.44E-01 |
PI3K (complex) | Cytoplasm | Complex | 196 | PIK3C2G | 12 | rs10770367 | 1.46 | 1.10E-03 |
IL12 (complex) | Extracellular space | Complex | 10 | IL12B | 5 | rs730691 | 0.77 | 1.68E-02 |
NFKB1 | Nucleus | Transcription regulator | 9 | NFKB1 | 4 | rs1609798 | 1.20 | 9.42E-02 |
TCR | Plasma membrane | Complex | 378 | TCRA | 14 | rs6572493 | 0.70 | 2.84E-03 |
Akt | Cytoplasm | Group | 33 | AKT2 | 19 | rs892120 | 1.35 | 3.15E-02 |
Fcer1 | Plasma membrane | Complex | 15 | FCER1G | 1 | rs11587213 | 0.68 | 1.68E-02 |
Cg | Other | Complex | 8 | CGA | 6 | rs9359730 | 1.26 | 3.48E-02 |
Interferon alpha | Extracellular space | Group | 14 | IFNA7 | 9 | rs4977686 | 1.20 | 7.51E-02 |