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Table 4 Top canonical pathways discovered by the IPA core analyses of the focus genes reported to be associated with cancer pain in the literature. The pathways listed have over-representation of focus genes. The canonical pathways were ranked by ratiosa

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

Canonical pathways

p values

Ratio

Airway Inflammation in Asthma

3.02E-08

75.0 %

Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17 F

2.09E-10

27.8 %

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17 F

8.13E-10

21.7 %

TNFR2 Signaling

2.34E-09

17.9 %

Role of Cytokines in Mediating Communication between Immune Cells

6.31E-16

17.3 %

IL-10 Signaling

7.94E-17

14.7 %

Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

1.82E-10

14.6 %

T Helper Cell Differentiation

6.31E-13

11.9 %

Graft-versus-Host Disease Signaling

2.51E-08

11.4 %

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.98E-14

11.1 %

IL-6 Signaling

3.16E-18

10.3 %

Hepatic Cholestasis

3.16E-24

10.1 %

PPAR Signaling

1.26E-13

10.0 %

Activation of IRF by Cytosolic Pattern Recognition Receptors

1.95E-09

10.0 %

Role of PKR in Interferon Induction and Antiviral Response

1.20E-06

10.0 %

Communication between Innate and Adaptive Immune Cells

3.98E-12

9.8 %

Role of IL-17 F in Allergic Inflammatory Airway Diseases

1.32E-06

9.8 %

HMGB1 Signaling

3.16E-16

9.3 %

Hematopoiesis from Pluripotent Stem Cells

1.78E-06

9.1 %

TREM1 Signaling

4.68E-09

8.7 %

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

2.51E-14

8.4 %

Allograft Rejection Signaling

2.51E-06

8.3 %

Crosstalk between Dendritic Cells and Natural Killer Cells

4.37E-10

7.9 %

CD40 Signaling

1.74E-07

7.8 %

Type I Diabetes Mellitus Signaling

3.16E-11

7.6 %

IL-15 Signaling

2.00E-07

7.6 %

LXR/RXR Activation

1.58E-12

7.4 %

Role of IL-17A in Arthritis

4.07E-06

7.4 %

Toll-like Receptor Signaling

3.09E-07

6.9 %

Induction of Apoptosis by HIV1

5.75E-06

6.8 %

PXR/RXR Activation

7.59E-06

6.4 %

Hepatic Fibrosis/Hepatic Stellate Cell Activation

2.00E-15

6.1 %

Atherosclerosis Signaling

3.63E-09

5.8 %

Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

6.31E-15

5.6 %

Dendritic Cell Maturation

3.98E-11

5.3 %

NF-κB Signaling

3.98E-11

5.3 %

p38 MAPK Signaling

1.12E-07

5.1 %

Glucocorticoid Receptor Signaling

1.26E-15

5.0 %

Acute Phase Response Signaling

1.20E-09

4.8 %

LPS/IL-1 Mediated Inhibition of RXR Function

2.29E-10

4.3 %

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

2.00E-13

4.2 %

Granulocyte Adhesion and Diapedesis

3.31E-08

4.2 %

FXR/RXR Activation

4.90E-06

4.0 %

IL-12 Signaling and Production in Macrophages

6.17E-06

3.8 %

PPARα/RXRα Activation

8.71E-07

3.6 %

Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

1.38E-06

3.4 %

  1. aRatio is calculated as the number of focus genes included in a canonical pathway divided by total number of genes that make up the canonical pathway