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Table 4 Top canonical pathways discovered by the IPA core analyses of the focus genes reported to be associated with cancer pain in the literature. The pathways listed have over-representation of focus genes. The canonical pathways were ranked by ratiosa

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

Canonical pathways p values Ratio
Airway Inflammation in Asthma 3.02E-08 75.0 %
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17 F 2.09E-10 27.8 %
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17 F 8.13E-10 21.7 %
TNFR2 Signaling 2.34E-09 17.9 %
Role of Cytokines in Mediating Communication between Immune Cells 6.31E-16 17.3 %
IL-10 Signaling 7.94E-17 14.7 %
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza 1.82E-10 14.6 %
T Helper Cell Differentiation 6.31E-13 11.9 %
Graft-versus-Host Disease Signaling 2.51E-08 11.4 %
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 3.98E-14 11.1 %
IL-6 Signaling 3.16E-18 10.3 %
Hepatic Cholestasis 3.16E-24 10.1 %
PPAR Signaling 1.26E-13 10.0 %
Activation of IRF by Cytosolic Pattern Recognition Receptors 1.95E-09 10.0 %
Role of PKR in Interferon Induction and Antiviral Response 1.20E-06 10.0 %
Communication between Innate and Adaptive Immune Cells 3.98E-12 9.8 %
Role of IL-17 F in Allergic Inflammatory Airway Diseases 1.32E-06 9.8 %
HMGB1 Signaling 3.16E-16 9.3 %
Hematopoiesis from Pluripotent Stem Cells 1.78E-06 9.1 %
TREM1 Signaling 4.68E-09 8.7 %
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 2.51E-14 8.4 %
Allograft Rejection Signaling 2.51E-06 8.3 %
Crosstalk between Dendritic Cells and Natural Killer Cells 4.37E-10 7.9 %
CD40 Signaling 1.74E-07 7.8 %
Type I Diabetes Mellitus Signaling 3.16E-11 7.6 %
IL-15 Signaling 2.00E-07 7.6 %
LXR/RXR Activation 1.58E-12 7.4 %
Role of IL-17A in Arthritis 4.07E-06 7.4 %
Toll-like Receptor Signaling 3.09E-07 6.9 %
Induction of Apoptosis by HIV1 5.75E-06 6.8 %
PXR/RXR Activation 7.59E-06 6.4 %
Hepatic Fibrosis/Hepatic Stellate Cell Activation 2.00E-15 6.1 %
Atherosclerosis Signaling 3.63E-09 5.8 %
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 6.31E-15 5.6 %
Dendritic Cell Maturation 3.98E-11 5.3 %
NF-κB Signaling 3.98E-11 5.3 %
p38 MAPK Signaling 1.12E-07 5.1 %
Glucocorticoid Receptor Signaling 1.26E-15 5.0 %
Acute Phase Response Signaling 1.20E-09 4.8 %
LPS/IL-1 Mediated Inhibition of RXR Function 2.29E-10 4.3 %
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 2.00E-13 4.2 %
Granulocyte Adhesion and Diapedesis 3.31E-08 4.2 %
FXR/RXR Activation 4.90E-06 4.0 %
IL-12 Signaling and Production in Macrophages 6.17E-06 3.8 %
PPARα/RXRα Activation 8.71E-07 3.6 %
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 1.38E-06 3.4 %
  1. aRatio is calculated as the number of focus genes included in a canonical pathway divided by total number of genes that make up the canonical pathway
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