Skip to main content

Table 1 Top 10 GO terms significantly enriched (FDR < 0.01) in lung focally exposed to high-dose radiation of 90 Gy

From: Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues

Focally irradiated area

  

Pattern 1

Pattern 2

Pattern 3

GO ID

Name

p-value*

FDRa

ID

Name

p-value

FDR

ID

Name

p-value

FDR

GO:0016337

Cell-cell adhesion

7.33E-10

2.67E-06

GO:0006955

Immune response

2.64E-63

5.58E-60

GO:0007050

Cell cycle arrest

4.29E-07

2.24E-04

GO:0007507

Heart development

9.75E-10

1.77E-06

GO:0006952

Defense response

4.26E-30

4.50E-27

GO:0022402

Cell cycle process

7.63E-07

2.52E-04

GO:0007155

Cell adhesion

3.99E-09

4.85E-06

GO:0006954

Inflammatory response

1.16E-26

8.20E-24

GO:0008219

Cell death

5.86E-06

9.93E-04

GO:0022610

Biological adhesion

3.99E-09

4.85E-06

GO:0009611

Response to wounding

4.72E-26

2.49E-23

GO:0016265

Death

6.77E-06

1.14E-03

GO:0006355

Regulation of transcription, DNA-dependent

1.48E-08

1.35E-05

GO:0002684

Positive regulation of immune system process

6.73E-21

2.84E-18

GO:0006915

Apoptosis

2.68E-05

2.49E-03

GO:0008016

Regulation of heart contraction

2.56E-08

1.87E-05

GO:0001775

Cell activation

7.44E-18

2.62E-15

GO:0007049

Cell cycle

2.79E-05

2.72E-03

GO:0007156

Homophilic cell adhesion

3.02E-08

1.83E-05

GO:0050778

Positive regulation of immune response

1.01E-17

3.05E-15

GO:0012501

Programmed cell death

2.98E-05

3.13E-03

GO:0051252

Regulation of RNA metabolic process

3.65E-08

1.90E-05

GO:0002252

Immune effector process

1.52E-17

4.01E-15

    

GO:0048562

Embryonic organ morphogenesis

9.21E-08

4.19E-05

GO:0045321

Leukocyte activation

2.21E-16

5.22E-14

    

GO:0007389

Pattern specification process

2.20E-07

8.89E-05

GO:0048584

Positive regulation of response to stimulus

2.88E-15

6.10E-13

    

Neighboring area

  

Pattern 1

Pattern 2

Pattern 3

ID

Name

p-value

FDR

ID

Name

p-value

FDR

ID

Name

p-value

FDR

GO:0006355

Regulation of transcription, DNA-dependent

4.16E-08

1.56E-04

GO:0006955

Immune response

2.00E-33

2.16E-30

NA

NA

NA

NA

GO:0051252

Regulation of RNA metabolic process

1.03E-07

1.94E-04

GO:0006954

Inflammatory response

2.39E-14

1.29E-11

    
    

GO:0006952

Defense response

1.23E-13

4.42E-11

    
    

GO:0009611

Response to wounding

1.63E-11

4.40E-09

    
    

GO:0042330

Taxis

2.75E-08

5.94E-06

    
    

GO:0006935

Chemotaxis

2.75E-08

5.94E-06

    
    

GO:0009615

Response to virus

9.79E-06

1.75E-03

    
    

GO:0002526

Acute inflammatory response

2.03E-05

3.12E-03

    
    

GO:0007626

Locomotory behavior

4.72E-05

6.34E-03

    
    

GO:0002684

Positive regulation of immune system process

6.48E-05

7.74E-03

    
  1. aFDR corrections were calculated using the Benjamini-Hochberg procedure
  2. *p-values were calculated using Fischer’s test