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Table 6 Associations Between rs6311 or rs6313 and RNA Expression

From: Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus: identification of novel HTR2A and antisense (HTR2A-AS1) exons

 

rs6311

rs6313

Gene

G/G (n)

G/A (n)

A/A (n)

P-Valuea

Adjusted P-Value

C/C (n)

C/T (n)

T/T (n)

P-Valuea

Adjusted P-Value

HTR2A-AS1 Unique Readsb

34.7 (69)

42.0 (106)

40.8 (26)

0.0070

0.4204

35.1 (73)

42.0 (103)

40.3 (25)

0.0153

0.9163

HTR2A Unique Readsc

4305.0 (71)

4525.7 (111)

3856.6 (26)

0.3026

1.0000

4262.2 (75)

4571.2 (108)

3934.5 (25)

0.3203

1.0000

HTR2A, AS1 Overlapping Readsd

69.9 (71)

75.8 (111)

62.0 (26)

0.3595

1.0000

69.2 (75)

75.8 (108)

63.9 (25)

0.4112

1.0000

Exon

HTR2A-AS1 Exon 14 Readse

13.2 (71)

17.2 (111)

16.7 (26)

0.0004

0.0212

13.4 (75)

17.2 (108)

16.6 (25)

0.0010

0.0586

HTR2A-AS1 Exon 17.1 Readsf

16.4 (69)

21.3 (106)

19.6 (26)

0.0011

0.0687

16.6 (73)

21.3 (103)

19.6 (25)

0.0030

0.1771

Junction Reads

HTR2A-AS1 Exon 14 to 17.1 Readsg

7.9 (69)

10.3 (108)

9.8 (27)

0.0069

0.4169

8.1 (73)

10.2 (105)

9.8 (26)

0.0142

0.8532

  1. Count values in the table are model predicted least square means. Differences in the subject numbers across outcomes reflect missing data in the selected variables for each model
  2. aCalculated using a negative binomial generalized linear model with selection of covariates via Bayesian Information Criterion (BIC)
  3. Covariates: balcohol use, RNA Integrity Number; cgender, pH, RNA Integrity Number; dgender, age, pH, RNA Integrity Number; eRNA Integrity Number; falcohol use, post-mortem interval, RNA Integrity Number; galcohol use