Chr | QTL | Locus A (Mbp) | Main A | Chr | QTL | Locus B (Mbp) | Main B | LOD T | LOD I | Trait (F2) |
---|
4 |
AS-m1
| SNP2789717 (173.96) | 1.2 | 16 |
AS-m2
| SNP2800810 (15.73) | 0.1 | 8.8 | 7.6 | PWVaorta (M) |
9 |
AS-f1
| SNP2795465 (30.75) | 2.8 | 11 |
AS-f2
| SNP2797258 (23.12) | 2.1 | 8.9 | 4.0 | PWVaorta (F) |
3 |
AS-1
| SNP2787751 (50.64) | 4.3 |  |  |  |  |  |  | STRaorta (M + F) |
-
QTL quantitative trait locus, Chr chromosome, PWV
aorta
Pulse Wave Velocity in aorta, STR
aorta
strain in aorta, M F2 male cohort, F F2 female cohort, LOD logarithm of the odds score derived from the likelihood ratio statistic using a factor of 4.6. For marker regression analysis significance was determined from 2000 permutations on data set: LOD 4.3 highly significant. Only interactive loci that exhibited a LOD > 8.0 (P < 10−5) for the total effect and a LOD > 4.0 (P < 0.01) for the interactive effect are presented. Main A and Main B refer to the specific LOD for A and B main (single locus) effects respectively. LOD T, LOD for total effect; LOD I, LOD for the interaction. SNP locations on rat genome as per NCBI Rat Genome Assembly Annotation Release 105