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Table 3 Arterial stiffness (AS) QTLs detected by marker regression and interaction analysis in F2 (Dahl S x R)-intercross rats

From: Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats

Chr

QTL

Locus A (Mbp)

Main A

Chr

QTL

Locus B (Mbp)

Main B

LOD T

LOD I

Trait (F2)

4

AS-m1

SNP2789717 (173.96)

1.2

16

AS-m2

SNP2800810 (15.73)

0.1

8.8

7.6

PWVaorta (M)

9

AS-f1

SNP2795465 (30.75)

2.8

11

AS-f2

SNP2797258 (23.12)

2.1

8.9

4.0

PWVaorta (F)

3

AS-1

SNP2787751 (50.64)

4.3

      

STRaorta (M + F)

  1. QTL quantitative trait locus, Chr chromosome, PWV aorta Pulse Wave Velocity in aorta, STR aorta strain in aorta, M F2 male cohort, F F2 female cohort, LOD logarithm of the odds score derived from the likelihood ratio statistic using a factor of 4.6. For marker regression analysis significance was determined from 2000 permutations on data set: LOD 4.3 highly significant. Only interactive loci that exhibited a LOD > 8.0 (P < 10−5) for the total effect and a LOD > 4.0 (P < 0.01) for the interactive effect are presented. Main A and Main B refer to the specific LOD for A and B main (single locus) effects respectively. LOD T, LOD for total effect; LOD I, LOD for the interaction. SNP locations on rat genome as per NCBI Rat Genome Assembly Annotation Release 105