High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population

Table 4 Correlation matrix between line means of all traits on high-fat dietary challenge (HFD, 42 % fat) within sexes (females, above the diagonal; males, below the diagonal) ^a. BW, Body Weight; BMI, Body Mass Index; WC, Waist circumference; Total AUC, total area under curve of the intraperitoneal glucose tolerance test; Initial, measurements at experiment start-point age of 8 weeks; End, end time-point of the experiment after 12 weeks high-fat dietary challenge; Gain, difference between end and initial time-point values

Trait	BW Initial	BMI Initial	WC Initial	BW End	BMI End	WC End	BW Gain	BMI Gain	WC Gain	Fasting Glucose	Total AUC
BW Initial	1	0.227	0.520*	0.636**	0.507*	0.550**	0.280	0.266	0.148	0.003	−0.171
BMI Initial	0.435*	1	0.010	−0.110	0.188	−0.153	−0.253	−0.557**	−0.165	−0.142	−0.350
WC Initial	0.728**	0.301	1	0.406	0.506*	0.417	0.240	0.421	−0.371	0.172	0.254
BW End	0.875**	0.473*	0.660**	1	0.778**	0.828**	0.919**	0.737**	0.522*	0.208	0.345
BMI End	0.778**	0.342	0.688**	0.827**	1	0.678**	0.709**	0.711**	0.290	0.070	0.274
WC End	0.735**	0.446*	0.591**	0.816**	0.715**	1	0.749**	0.684**	0.690**	0.094	0.379
BW Gain	0.710**	0.443*	0.551**	0.962**	0.765**	0.773**	1	0.781**	0.574**	0.257	0.517*
BMI Gain	0.594**	−0.155	0.568**	0.626**	0.875**	0.522*	0.576**	1	0.363	0.161	0.482*
WC Gain	0.355	0.322	−0.032	0.506*	0.360	0.788**	0.537*	0.213	1	−0.041	0.185
Fasting Glucose	−0.121	0.176	−0.315	−0.085	−0.310	0.020	−0.056	−0.416	0.265	1	0.597**
Total AUC	−0.347	0.101	−0.171	−0.106	−0.316	−0.026	0.042	−0.384	0.098	0.585**	1

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