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Table 1 Broad sense heritability (H2) and genetic coefficient of variation (CVg) of the tested traits under high fat diet (HFD, 42 % fat) and chow (CH, 18 % fat) diets, separately for females and males. Initial, end, trait value at start 8 weeks) and end (20 weeks) of HFD challenge period. Gain, end trait-value minus initial trait-value. Total AUC, area under the curve for intraperitoneal glucose tolerance test between 0 and 180 min from start of test. ND, not done (see text for explanations). Table 1 also shows H2n calculated for the average animals per line (n) values of our data: 5.52 for females-HFD, 7.09 for males-HFD, 8.55 for females-Chow, and 11.95 for males-Chow a

From: High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population

Trait

Females

Males

 

CH Diet

HF Diet

CH Diet

HF Diet

 

H2

H2n

CVg

H2

H2n

CVg

H2

H2n

CVg

H2

H2n

CVg

BW Initial

0.37

0.89

0.08

0.37

0.76

0.08

0.37

0.92

0.09

0.37

0.81

0.09

BMI Initial

0.47

0.92

0.14

0.47

0.83

0.14

0.33

0.90

0.09

0.33

0.78

0.09

WC Initial

0.54

0.94

0.13

0.54

0.87

0.13

0.38

0.92

0.10

0.38

0.81

0.10

BW End

0.57

0.95

0.14

0.56

0.88

0.16

0.55

0.96

0.16

0.47

0.86

0.15

BMI End

0.40

0.90

0.12

0.57

0.88

0.16

0.52

0.95

0.13

0.43

0.84

0.16

WC End

0.46

0.92

0.12

0.48

0.84

0.16

0.25

0.86

0.07

0.29

0.74

0.13

BW Gain

0.53

0.94

ND

0.51

0.85

ND

0.33

0.90

ND

0.38

0.81

ND

BMI Gain

0.56

0.94

ND

0.32

0.72

ND

0.24

0.85

ND

0.36

0.80

ND

WC Gain

0.56

0.94

ND

0.46

0.82

ND

0.11

0.70

ND

0.17

0.59

ND

Fasting Glucose

0.38

0.89

0.13

0.26

0.66

0.16

0.44

0.94

0.17

0.24

0.69

0.13

Total AUC

0.42

0.91

0.15

0.43

0.81

0.27

0.24

0.85

0.17

0.37

0.81

0.21

Mean

0.49

0.93

0.13

0.47

0.83

0.16

0.33

0.90

0.12

0.36

0.80

0.13

  1. a No. of animals (in parentheses, mean number of animals per line): HFD, males and females, 21 lines, 116 females (5.52), 149 males (7.09); Chow diet, numbers varied somewhat according to sex and trait. On average there were for males 20 lines average 11.95 mice per line; for females 17 lines, average 8,55 mice per line