Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Davis, Sharon K.; Xu, Ruihua; Gebreab, Samson Y.; Riestra, Pia; Gaye, Amadou; Khan, Rumana J.; Wilson, James G.; Bidulescu, Aurelian

doi:10.1186/s12863-015-0319-4

Table 7 Association between BMI and ADIPOQ SNPs among men and women in the Jackson Heart Study, N = 3,015*

From: Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Men, n = 1,150
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β(SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	0.02(0.01)	0.2907	0.01(0.01)	0.3250	0.02(0.02)	0.2014	0.001(0.01)	0.9212	0.001(0.01)	0.9286	−0.01(0.01)	0.9369
rs12495941	G/T	0.04(0.04)	0.3020	0.03(0.04)	0.3923	0.06(0.05)	0.2288	−0.02(0.04)	0.5470	−0.04(0.04)	0.3368	−0.04(0.04)	0.2705
rs7627128	C/A	−0.09(0.06)	0.1112	−0.10(0.06)	0.0656	−0.12(0.08)	0.1383	−0.01(0.05)	0.9122	−0.01(0.05)	0.9111	−0.002(0.05)	0.9631
rs9877202	A/G	0.01(0.02)	0.4062	0.01(0.02)	0.3984	0.002(0.02)	0.8888	−0.003(0.01)	0.8100	0.004(0.01)	0.7816	0.006(0.01)	0.7000
rs2036373	T/G	0.18(0.15)	0.2362	0.19(0.15)	0.2090	0.09(0.18)	0.6042	0.03(0.12)	0.8097	0.06(0.13)	0.6559	0.06(0.13)	0.6333
rs1501299	G/T	−0.01(0.02)	0.5381	−0.01(0.02)	0.5427	−0.02(0.02)	0.4453	−0.003(0.02)	0.8198	−0.01(0.02)	0.7433	−0.004(0.02)	0.7959
rs3821799	T/C	0.01(0.01)	0.5231	0.01(0.01)	0.4373	0.01(0.01)	0.4451	0.01(0.01)	0.3572	0.01(0.01)	0.2271	0.01(0.01)	0.3012
rs9842733	A/T	−0.05(0.06)	0.4189	−0.04(0.06)	0.4565	−0.03(0.07)	0.6265	0.01(0.05)	0.8381	0.02(0.05)	0.6911	0.01(0.05)	0.7695
Women, n = 1,865
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	0.01(0.01)	0.5560	0.01(0.01)	0.5908	0.02(0.02)	0.3135	0.01(0.01)	0.5001	0.002(0.01)	0.8239	0.004(0.01)	0.7495
rs12495941	G/T	0.06(0.03)	0.0447	0.05(0.03)	0.0724	0.05(0.04)	0.2977	0.01(0.03)	0.7523	0.01(0.03)	0.6878	0.01(0.03)	0.7813
rs7627128	C/A	0.001(0.05)	0.9921	−0.01(0.05)	0.8213	0.06(0.07)	0.4078	0.09(0.06)	0.1436	0.09(0.06)	0.1172	0.09(0.06)	0.1307
rs9877202	A/G	−0.01(0.02)	0.7077	−0.01(0.02)	0.7377	0.002(0.02)	0.9166	−0.01(0.01)	0.3950	−0.01(0.02)	0.5705	−0.01(0.02)	0.5568
rs2036373	T/G	−0.07(0.13)	0.5655	−0.05(0.13)	0.6915	−0.05(0.14)	0.6920	−0.05(0.11)	0.6477	−0.02(0.12)	0.8414	−0.03(0.12)	0.7874
rs1501299	G/T	0.01(0.02)	0.7208	0.01(0.02)	0.6198	0.01(0.02)	0.5665	−0.01(0.02)	0.4194	−0.02(0.02)	0.3642	−0.02(0.02)	0.3543
rs3821799	T/C	0.002(0.01)	0.8623	0.002(0.01)	0.8598	0.005(0.01)	0.7169	−0.0001(0.01)	0.9897	0.003(0.01)	0.7858	0.004(0.01)	0.7302
rs9842733	A/T	0.03(0.04)	0.4526	0.02(0.04)	0.5909	0.07(0.05)	0.1991	0.06(0.04)	0.1338	0.06(0.04)	0.1485	0.06(0.04)	0.1391

^*N represents 5 missing values for BMI
^┼Model 1: crude
^╪Model 2: adjusted for age
^§Model 3: adjusted for age, PEA
^║Model 4: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma peptin
^¶Model 5: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, smoking status, physical activity score, alcohol consumption status
^#Model 6: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, smoking status, physical activity score, alcohol consumption status, socioeconomic status (education level)
Two-tailed level of significance established as P ≤ 0.006

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