Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Davis, Sharon K.; Xu, Ruihua; Gebreab, Samson Y.; Riestra, Pia; Gaye, Amadou; Khan, Rumana J.; Wilson, James G.; Bidulescu, Aurelian

doi:10.1186/s12863-015-0319-4

Table 6 Association between HOMA-IR and ADIPOQ SNPs among men and women in the Jackson Heart Study, N = 2,347*

From: Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Men, n = 920
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	0.04(0.05)	0.3782	0.04(0.05)	0.3939	0.04(0.06)	0.4916	−0.03(0.05)	0.5570	−0.04(0.05)	0.4126	−0.05(0.05)	0.3641
rs12495941	G/T	0.43(0.14)	0.001	0.43(0.14)	0.002	0.76(0.18)	<.0001	0.41(0.15)	0.004	0.42(0.15)	0.005	0.40(0.15)	0.0086
rs7627128	C/A	−0.98(0.20)	<.0001	−0.99(0.20)	<.0001	−0.13(0.26)	<.0001	−0.78(0.20)	0.0001	−0.74(0.20)	0.0002	−0.73(0.20)	0.0003
rs9877202	A/G	−0.002(0.06)	0.9784	−0.001(0.06)	0.9913	−0.02(0.07)	0.7451	−0.03(0.05)	0.5270	−0.04(0.06)	0.4308	−0.05(0.06)	0.3797
rs2036373	T/G	0.42(0.51)	0.4158	0.42(0.51)	0.4102	0.06(0.63)	0.9262	−0.15(0.49)	0.7626	−0.05(0.52)	0.9197	−0.07(0.52)	0.8889
rs1501299	G/T	−0.05(0.06)	0.3976	−0.05(0.06)	0.3886	−0.03(0.07)	0.7110	−0.02(0.06)	0.7035	−0.04(0.06)	0.5522	−0.03(0.06)	0.6309
rs3821799	T/C	0.03(0.04)	0.4645	0.03(0.04)	0.4422	0.05(0.05)	0.2534	0.08(0.04)	0.0258	0.07(0.04)	0.0638	0.07(0.04)	0.0608
rs9842733	A/T	0.11(0.18)	0.5344	0.12(0.18)	0.5306	0.17(0.26)	0.4427	0.18(0.18)	0.3151	0.07(0.19)	0.6947	0.07(0.19)	0.6955
Women, n = 1,427
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β(SE)	P-value	β(SE)	P-value	β(SE)	P-value	β(SE)	P-value	β(SE)	P-value	β(SE)	P-value
rs16861205	G/A	0.07(0.04)	0.0795	0.07(0.04)	0.0776	0.06(0.04)	0.1816	0.07(0.04)	0.0491	0.07(0.04)	0.0594	0.07(0.04)	0.0624
rs12495941	G/T	0.11(0.08)	0.1814	0.12(0.08)	0.1510	0.11(0.11)	0.3332	0.01(0.10)	0.8898	0.01(0.10)	0.9282	0.004(0.10)	0.9626
rs7627128	C/A	−0.12(0.16)	0.4349	−0.11(0.16)	0.4908	0.001(0.21)	0.9959	0.08(0.17)	0.6421	0.05(0.17)	0.7616	0.05(0.17)	0.7874
rs9877202	A/G	−0.01(0.05)	0.8391	−0.01(0.05)	0.7704	0.05(0.05)	0.3250	0.01(0.04)	0.8426	0.01(0.05)	0.7866	0.01(0.05)	0.8183
rs2036373	T/G	−0.01(0.34)	0.9876	−0.02(0.34)	0.9438	−0.05(0.36)	0.8922	−0.002(0.3)	0.9933	−0.11(0.36)	0.7577	−0.10(0.36)	0.7696
rs1501299	G/T	0.15(0.05)	0.003	0.14(0.05)	0.003	0.13(0.06)	0.0226	0.06(0.05)	0.2300	0.08(0.05)	0.0996	0.08(0.05)	0.1006
rs3821799	T/C	0.01(0.03)	0.8004	0.01(0.03)	0.7921	−0.01(0.04)	0.7620	−0.02(0.03)	0.5097	−0.03(0.03)	0.3304	−0.03(0.03)	0.3290
rs9842733	A/T	0.30(0.16)	0.0176	0.31(0.13)	0.0139	0.29(0.15)	0.0539	0.33(0.13)	0.0098	0.27(0.13)	0.0385	0.28(0.13)	0.0337

^*N represents 673 missing values for HOMA-IR
^┼Model 1: crude
^╪Model 2: adjusted for age
^§Model 3: adjusted for age, PEA
^║Model 4: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin
^¶Model 5: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, smoking status, physical activity score, BMI, alcohol consumption status
^#Model 6: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, smoking status, physical activity score, BMI, alcohol consumption status, socioeconomic status (education level)
Two-tailed level of significance established as P ≤ 0.006

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