Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Davis, Sharon K.; Xu, Ruihua; Gebreab, Samson Y.; Riestra, Pia; Gaye, Amadou; Khan, Rumana J.; Wilson, James G.; Bidulescu, Aurelian

doi:10.1186/s12863-015-0319-4

Table 5 Association between blood glucose and ADIPOQ SNPs among men and women in the Jackson Heart Study, N = 2,800*

From: Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Men, n = 1,071
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	0.01(0.02)	0.4877	0.02(0.02)	0.3755	0.03(0.02)	0.2168	0.01(0.02)	0.6174	0.004(0.02)	0.8347	0.005(0.02)	0.8140
rs12495941	G/T	0.03(0.05)	0.5088	0.04(0.04)	0.3695	0.03(0.06)	0.6776	−0.001(0.06)	0.9887	−0.02(0.07)	0.7920	−0.03(0.07)	0.6549
rs7627128	C/A	−0.05(0.07)	0.4997	−0.03(0.001)	0.7078	−0.01(0.09)	0.9074	0.02(0.09)	0.8449	0.03(0.09)	0.7506	0.04(0.09)	0.6765
rs9877202	A/G	−0.01(0.02)	0.7960	−0.01(0.02)	0.7940	−0.01(0.02)	0.6964	−0.004(0.02)	0.8658	−0.01(0.02)	0.6983	−0.01(0.02)	0.5648
rs2036373	T/G	−0.19(0.19)	0.3200	−0.20(0.18)	0.2764	−0.38(0.21)	0.0694	−0.38(0.20)	0.0489	−0.46(0.21)	0.0262	−0.45(0.20)	0.0289
rs1501299	G/T	−0.01(0.02)	0.6674	−0.01(0.02)	0.6454	−0.001(0.03)	0.9726	−0.01(0.02)	0.6306	−0.01(0.03)	0.6235	−0.01(0.03)	0.6798
rs3821799	T/C	0.005(0.01)	0.7486	0.002(0.01)	0.8970	0.0004(0.02)	0.9764	0.01(0.02)	0.6961	0.01(0.02)	0.6086	0.01(0.02)	0.6701
rs9842733	A/T	0.09(0.07)	0.2152	0.08(0.07)	0.2207	0.06(0.08)	0.4388	0.04(0.08)	0.6100	0.05(0.08)	0.5668	0.05(0.08)	0.5539
Women, n = 1,729
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	0.02(0.02)	0.1881	0.004(0.01)	0.1790	0.01(0.02)	0.3971	0.02(0.02)	0.1640	0.02(0.02)	0.2073	0.02(0.02)	0.1810
rs12495941	G/T	−0.003(0.03)	0.9296	0.01(0.03)	0.7260	0.04(0.04)	0.4129	0.02(0.04)	0.6438	0.01(0.04)	0.7305	0.01(0.04)	0.7427
rs7627128	C/A	−0.01(0.06)	0.8482	0.02(0.06)	0.7974	0.08(0.08)	0.2949	0.11(0.08)	0.1639	0.10(0.08)	0.2094	0.09(0.08)	0.2248
rs9877202	A/G	−0.03(0.02)	0.0672	−0.04(0.02)	0.0338	−0.01(0.02)	0.4711	−0.02(0.02)	0.2251	−0.02(0.02)	0.3394	−0.02(0.02)	0.3012
rs2036373	T/G	0.07(0.14)	0.6170	0.03(0.14)	0.8356	−0.01(0.14)	0.9198	0.01(0.13)	0.9309	−0.03(0.16)	0.8586	−0.03(0.16)	0.8422
rs1501299	G/T	0.02(0.02)	0.3343	0.02(0.02)	0.4112	0.002(0.02)	0.9379	−0.01(0.02)	0.5848	−0.01(0.02)	0.7571	−0.01(0.02)	0.7473
rs3821799	T/C	0.01(0.01)	0.4056	0.01(0.01)	0.4642	−0.003(0.01)	0.8430	0.01(0.01)	0.6920	0.01(0.01)	0.6938	0.01(0.01)	0.6240
rs9842733	A/T	0.02(0.05)	0.6652	0.03(0.05)	0.4631	0.02(0.05)	0.7694	0.04(0.05)	0.4431	0.02(0.05)	0.6909	0.03(0.05)	0.6373

^*N represents 220 missing values for blood glucose
^┼Model 1: crude
^╪Model 2: adjusted for age
^§Model 3: adjusted for age, PEA
^║Model 4: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin
^¶Model 5: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, smoking status, physical activity score, BMI, alcohol consumption status
^#Model 6: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin,, smoking status, physical activity score, BMI, alcohol consumption status, socioeconomic status (education level)
Two-tailed level of significance was established as P ≤ 0.006

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