Fig. 2

Simplified sketches of the underlying biological models and assumptions of the working group papers. BP _i , BP measure at the i ^th visit; DBP, diastolic blood pressure; GE, gene expression; LBP, latent variable affecting both systolic and diastolic blood pressure; MURAT, multivariate rare-variant association test; SBP, systolic blood pressure; SEM, structural equation modeling; SNV, single nucleotide variant; SRVS, sparse representation-based variable selection. For a more detailed presentation of the models, please refer to the original articles