Pathway-based analyses

BMC Genomic Data

Table 2 Summary of research approaches: Data used

Contribution	Genomic data	Cohort	Phenotype category	Phenotype(s)
Brunel	Gene expression/GWAS	Families	Real (gene expression)	Derived^a
Kos	GWAS and exomic variants	Families	Simulated^b	DBP (first visit)
Lo	GWAS and exomic variants	Unrelated	Real	DBP (first visit)
Quillen	Gene expression	Families	Simulated^b	DBP (first visit)
Tayo	GWAS and exomic variants	Unrelated	Simulated^b and real	DBP, SBP, HT, MAP
Valcarcel	GWAS and exomic variants	Families	Simulated^b	Means across visits of DBP, SBP, HT, MAP
Ziyatdinov	Gene expression	Families	Real	SBP

DBP diastolic blood pressure; GWAS, genome-wide association studies; HT hypertension; MAP mean arterial pressure; SBP, systolic blood pressure
^aIndependent components (see Table 3 and text)
^bAuthors were aware of simulation model “answers”

ISSN: 2730-6844