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Table 5 The list of the common genes with changed transcriptional activity in hypothalami of hypertensive ISIAH rats and hypertensive Schlager mice (26 weeks old), which represent a genetic model of neurogenic hypertension

From: Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Gene symbol

Acc.#

Gene definition

log2 (fold_change) ISIAH/WAG

Fold difference in Schlager miceb

Acer2

NM_001107943

alkaline ceramidase 2

0.60

1.69

Chi3l1 a

NM_053560

chitinase 3-like 1 (cartilage glycoprotein-39)

−1.27

−1.73

Fhit

NM_021774

fragile histidine triad

1.46

−1.3

Galc

NM_001005888

galactosylceramidase

−0.72

−1.42

Nkiras1

NM_001107252

NFKB inhibitor interacting Ras-like 1

0.59

1.19

Paqr5

NM_001014092

progestin and adipoQ receptor family member V

0.89

1.25

Tnnt1

NM_001277260

troponin T type 1 (skeletal, slow)

−4.37

−2.01

  1. a- Genes associated with hypertension; bValues represent mean of the fold difference between hypertensive and normotensive samples. Positive fold difference values indicate higher expression in hypertension and negative fold difference values indicate higher expression in normotension [45]