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Table 2 Genes differentially expressed in ISIAH and WAG hypothalami and referred to in Rat Genome Database as associated with central nervous system diseases

From: Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Gene symbol

Acc.#

Gene name

log2 fold_change ISIAH/WAG

Abca1 a

NM_178095

ATP-binding cassette, subfamily A (ABC1), member 1

0.65

Abcg2

NM_181381

ATP-binding cassette, subfamily G (WHITE), member 2

1.83

Adamts4 a,b,c

NM_023959

ADAM metallopeptidase with thrombospondin type 1 motif, 4

−0.59

Chi3l1 a,b

NM_053560

chitinase 3-like 1 (cartilage glycoprotein-39)

−1.27

Cst3 a,b,c

NM_012837

cystatin C

−0.59

Ctss a,b

NM_017320

cathepsin S

−0.50

Cyp11b2 b

NM_012538

cytochrome P450, family 11, subfamily b, polypeptide 2

1.06

Ephx2 b,d,c

NM_022936

epoxide hydrolase 2, cytoplasmic

4.40

Ercc2

NM_001172809

excision repair cross-complementation group 2

2.30

Fn1 a

NM_019143

fibronectin 1

−0.98

Galc

NM_001005888

galactosylceramidase

−0.72

Igf2 a,b,d,c

NM_001190162

insulin-like growth factor 2 (Igf2), transcript variant 2

−1.09

Igfbp2

NM_013122

insulin-like growth factor binding protein 2

−0.92

Mal

NM_012798

mal, T-cell differentiation protein

−0.72

P2ry12 a,b

NM_022800

purinergic receptor P2Y, G-protein coupled, 12

0.59

Prkcd a,b,c

NM_133307

protein kinase C, delta

0.63

Ptgds b

NM_013015

prostaglandin D2 synthase (brain)

−0.57

RGD1563482

NM_001109065

similar to hypothetical protein FLJ38663

0.79

RT1-Ba a,b,d,c

NM_001008831

RT1 class II, locus Ba

−0.80

RT1-Bb a,b

NM_001004084

RT1 class II, locus Bb

−1.26

RT1-Da a

NM_001008847

RT1 class II, locus Da

−0.63

RT1-Db1 a,b

NM_001008884

RT1 class II, locus Db1

−0.76

Selplg b

NM_001013230

selectin P ligand

−0.78

Slc6a3

NM_012694

solute carrier family 6 (neurotransmitter transporter), member 3

−1.34

Tgfb2 a

NM_031131

transforming growth factor, beta 2

0.85

Vtn a

NM_019156

vitronectin

−0.56

  1. Genes associated with: a- immune system diseases; b- cerebrovascular disorders; c- brain ischemia; d- brain infarction; ISIAH and WAG – rat strains used in the study