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Table 2 Genome-wide significant results for FEV1/FVC in the meta-analysis. The SNP with the lowest p value within each region or gene is listed ordered by chromosome number

From: A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

SNP Position (bp) CHR Nearest Gene Coded Allele COPDGene NHW COPDGene AA Meta-Analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS
Allele Freq Beta P Allele Freq Beta P Allele Freq Beta P
rs72738834 218623888 1 TGFB2 G/G/A 0.79 −0.01 0.00276 0.834 −0.017 5.34E-05 0.81 −0.013 6.51E-09
rs6837671 89873092 4 FAM13A G/G/A 0.60 −0.01 5.18E-06 0.416 0.007 0.03196 0.535 0.013 5.45E-13
rs13141641 145506456 4 LOC646576 (near HHIP) C/C/T 0.60 −0.02 5.72E-09 0.888 −0.015 0.00477 0.632 −0.018 9.52E-20
rs72981684 102724211 11 MMP12 T/T/T 0.88 −0.02 2.46E-07 0.968 −0.024 0.02783 0.114 0.019 3.92E-10
rs72981675 102721251 11 MMP3 T/T/T 0.88 −0.02 2.80E-07 0.968 −0.024 0.02842 0.114 0.019 3.65E-10
rs754388 93115410 14 RIN3 G/G/C 0.82 −0.02 3.17E-07 0.85 −0.01 0.00898 0.83 −0.014 5.54E-09
rs56077333 78899003 15 CHRNA3 A/A/A 0.65 −0.02 4.70E-10 0.816 0.019 6.02E-06 0.314 −0.018 9.55E-20
rs8042849 78817929 15 AGPHD1 C/C/T 0.56 0.02 2.71E-10 0.568 0.008 0.02729 0.561 0.015 2.81E-15
rs17486278 78867482 15 CHRNA5 C/C/A 0.63 0.02 2.28E-09 0.709 0.016 3.14E-06 0.65 0.017 4.48E-20
rs58365910 78849034 15 PSMA4 C/C/T 0.628 0.016 2.28E-09 0.747 0.011 0.00475 0.655 0.015 1.24E-15
rs17487223 78923987 15 CHRNB4 G/T/T 0.616 0.016 9.73E-09 0.882 0.013 0.00999 0.349 −0.016 3.28E-15
rs17484524 78772676 15 IREB2 G/G/A 0.639 0.015 1.86E-07 0.936 0.01 0.138 0.666 0.015 4.83E-13
rs12913260 79071095 15 ADAMTS7 A/A/A 0.59 0.02 1.60E-05 0.88 0.004 0.53 0.371 −0.015 4.82E-08
rs56113850 41353107 19 CYP2A6 T/C/T 0.60 −0.02 2.46E-05 0.562 0.01 0.01955 0.462 0.014 5.19E-09
  1. The “Coded Allele” column refers to the reference allele where the first reference allele is for the COPDGene NHW cohort, the second reference allele is for the COPDGene AA cohort, and the third reference allele is for the meta-analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS. Note that FEV1/FVC was measured on the proportion scale (0–1) and not the percentage scale (0–100)