Table 1 The 20 SNPs which are most associated with asthma, corrected by the first three principal components for ancestry
From: A genome-wide association study of asthma symptoms in Latin American children
Rank | Chromosome | SNP | Position (bp) | Risk Allele | MAF | Gene | Odds ratio | IC (95 %) | p |
|---|---|---|---|---|---|---|---|---|---|
1 | 14 | rs1999071 | 23129207 | C | 0.32 | Intergenic | 1.78 | (1.45 – 2.18) | 2.834 × 10−08 |
2 | 15 | rs10519031 | 60183005 | C | 0.04 | Intergenic | 3.01 | (2.02 – 4.49) | 6.676 × 10−08 |
3 | 15 | rs8029377 | 60191985 | C | 0.06 | Intergenic | 2.49 | (1.76 – 3.53) | 2.454 × 10−07 |
4 | 3 | rs77165709 | 159452876 | T | 0.08 | IQCJ-SCHIP1 | 2.27 | (1.66 – 3.18) | 3.045 × 10−07 |
5 | 10 | rs10159952 | 77562470 | A | 0.09 | C10orf11 | 2.04 | (1.53 – 2.72) | 1.016 × 10−06 |
6 | 9 | rs1329568 | 37037976 | T | 0.11 | LOC100130458 | 1.93 | (1.47 – 2.54) | 2.02 × 10−06 |
7 | 7 | rs1425883 | 49754984 | T | 0.36 | Intergenic | 0.60 | (0.49 – 0.74) | 2.037 × 10−06 |
8 | 7 | rs1543902 | 49754752 | G | 0.36 | Intergenic | 0.60 | (0.49 – 0.74) | 2.164 × 10−06 |
9 | 18 | rs76227669 | 10787366 | T | 0.02 | PIEZO2 | 4.06 | (2.24 – 7.36) | 3.881 × 10−06 |
10 | 9 | rs4878674 | 37036329 | T | 0.12 | Intergenic | 1.90 | (1.45 – 2.49) | 4.027 × 10−06 |
11 | 10 | rs1244495 | 7881339 | G | 0.38 | TAF3 | 0.61 | (0.50 – 0.75) | 4.169 × 10−06 |
12 | 1 | rs269330 | 68548590 | T | 0.16 | GNG12-AS1 | 1.75 | (1.38 – 2.22) | 4.669 × 10−06 |
13 | 7 | rs10268364 | 28708465 | C | 0.36 | CREB5 | 1.59 | (1.30 – 1.94) | 4.671 × 10−06 |
14 | 7 | rs41335 | 28704468 | C | 0.49 | CREB6 | 0.64 | (0.52 – 0.77) | 4.793 × 10−06 |
15 | 4 | rs72998173 | 173715118 | G | 0.14 | GALNTL6 | 1.76 | (1.38 – 2.24) | 4.848 × 10−06 |
16 | 3 | rs4373023 | 34077223 | T | 0.43 | Intergenic | 1.57 | (1.29 – 1.91) | 4.977 × 10−06 |
17 | 9 | rs1329567 | 37038326 | A | 0.09 | LOC100130458 | 1.97 | (1.47 – 2.64) | 5.46 × 10−06 |
18 | 9 | rs2381598 | 37041246 | C | 0.09 | Intergenic | 1.97 | (1.47 – 2.64) | 5.474 × 10−06 |
19 | 15 | rs12901887 | 56941976 | G | 0.23 | ZNF280D | 0.56 | (0.43 – 0.72) | 6.224 × 10−06 |
20 | 1 | rs79530846 | 171950308 | T | 0.03 | vDNM3 | 3.08 | (1.88 – 5.03) | 7.542 × 10−06 |