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Table 2 Allelic effects in different QTLs on plasma glucose and lipids of female F2 mice derived from BALB and SM Apoe −/− mice

From: Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains

Locus name

Chr

Trait

LOD

Peak (cM)

Closest marker

BB

SS

SB

Bglu16

9

Glucose-C

2.214

2.37

rs13480073

109.0 ± 28.7 (n = 44)

93.9 ± 22.9 (n = 43)

97.4 ± 22.6 (n = 141)

Bglu13

5

Glucose-W

2.1.8

67.4

rs3726547

144.4 ± 30.6 (n = 43)

153.5 ± 40.4 (n = 88)

142.9 ± 35.3 (n = 97)

-

5

Glucose-W

3.198

101.24

rs13478578

132.7 ± 31.3 (n = 51)

158.8 ± 41.8 (n = 63)

147.5 ± 34.0 (n = 113)

Bglu16

9

Glucose-W

3.12

2.37

rs13480073

165.3 ± 40.9 (n = 54)

138.3 ± 30.0 (n = 43)

144.4 ± 35.7 (n = 141)

Bglu17

9

Glucose-W

5.425

26.37

CEL.9_49183636

168.0 ± 39.8 (n = 42)

134.7 ± 26.5 (n = 62)

146.1 ± 37.1 (n = 124)

Hdlq5

1

HDL-C

8.64

93.52

rs13476259

49.5 ± 20.9 (n = 60)

73.2 ± 26.5 (n = 62)

55.1 ± 19.4 (n = 106)

Hdlcl1

7

HDL-C

2.668

61.33

rs3724711

49.0 ± 20.0 (n = 50)

58.3 ± 21.0 (n = 63)

62.9 ± 25.5 (n = 115)

Hdlq17

9

HDL-C

4.614

30.37

CEL.9_49183636

49.5 ± 15.9 (n = 42)

69.4 ± 26.8 (n = 62)

56.2 ± 22.5 (n = 124)

Hdlq26

10

HDL-C

2.181

61.22

rs3688351

50.7 ± 19.2 (n = 60)

59.4 ± 21.9 (n = 53)

62.4 ± 25.8 (n = 114)

Hdlq5

1

sqrtHDL-W

13.944

87.52

rs3685643

66.6 ± 50.2 (n = 57)

201.1 ± 118.8 (n = 62)

117.0 ± 97.1 (n = 109)

Hdlcl1

7

sqrtHDL-W

3.658

85.57

rs6216320

95.5 ± 87.6 (n = 63)

173.3 ± 126.7 (n = 55)

122.4 ± 98.4 (n = 110)

Hdlq17

9

sqrtHDL-W

10.625

30.42

CEL.9_49183636

57.6 ± 49.3 (n = 42)

183.3 ± 115.0 (n = 62)

122.8 ± 101.7 (n = 124)

Chol7

1

non-HDL-C

2.093

66.95

rs6354736

279.5 ± 62.8 (n = 56)

257.8 ± 56.9 (n = 57)

251.2 ± 52.1 (n = 114)

Nhdlq15

2

non-HDL-C

2.56

23.86

mCV23209429

273.9 ± 56.1 (n = 55)

238.0 ± 47.0 (n = 53)

262.7 ± 59.0 (n = 120)

Hdlq34

5

non-HDL-C

2.106

19.4

rs3658401

244.5 ± 54.7 (n = 63)

276.0 ± 53.2 (n = 61)

259.3 ± 58.3 (n = 104)

Pnhdlc1

6

non-HDL-C

2.489

57.53

rs13478909

279.6 ± 51.3 (n = 51)

252.0 ± 65.2 (n = 57)

254.8 ± 53.5 (n = 120)

Nhdlq1

8

non-HDL-C

2.221

44.14

D8Mit50

275.0 ± 54.5 (n = 60)

242.4 ± 57.4 (n = 57)

262.9 ± 55.6 (n = 96)

Nhdlq12

12

non-HDL-C

2.73

39.41

rs6195664

278.6 ± 52.3 (n = 62)

243.8 ± 57.8 (n = 59)

257.4 ± 56.5 (n = 107)

Nhdlq15

2

non-HDL-W

4.79

31.8

rs13476507

954.1 ± 156.0 (n = 56)

806.9 ± 158.2 (n = 47)

915.6 ± 166.1 (n = 125)

Nhdlq11

9

non-HDL-W

2.136

32.37

rs3709825

958.4 ± 211.4 (n = 42)

856.8 ± 165.3 (n = 62)

906.6 ± 149.5 (n = 124)

-

11

non-HDL-W

2.332

1.99

rs4222040

927.3 ± 149.8 (n = 67)

849.0 ± 165.1 (n = 69)

917.0 ± 170.5 (n = 85)

Nhdlq16

16

non-HDL-W

3.99

46.66

rs3721202

820.2 ± 152.7 (n = 56)

931.9 ± 146.4 (n = 52)

928.4 ± 174.6 (n = 120)

Tgq11

2

Triglyceride-C

2.952

26.73

mCV23209429

123.7 ± 35.7 (n = 55)

101.9 ± 34.6 (n = 53)

107.3 ± 31.8 (n = 120)

-

5

Triglyceride-C

2.759

80.03

gnf05.120.578

110.2 ± 33.2 (n = 43)

119.3 ± 35.8 (n = 88)

101.6 ± 31.3 (n = 97)

Trglyd

1

Triglyceride-W

3.291

97.02

rs13476259

94.0 ± 28.6 (n = 59)

115.3 ± 33.0 (n = 62)

100.7 ± 30.8 (n = 106)

Bglu16

9

Glucose-C

2.214

2.37

rs13480073

109.0 ± 28.7 (n = 44)

93.9 ± 22.9 (n = 43)

97.4 ± 22.6 (n = 141)

Bglu13

5

Glucose-W

2.1.8

67.4

rs3726547

144.4 ± 30.6 (n = 43)

153.5 ± 40.4 (n = 88)

142.9 ± 35.3 (n = 97)

-

5

Glucose-W

3.198

101.24

rs13478578

132.7 ± 31.3 (n = 51)

158.8 ± 41.8 (n = 63)

147.5 ± 34.0 (n = 113)

Bglu16

9

Glucose-W

3.12

2.37

rs13480073

165.3 ± 40.9 (n = 54)

138.3 ± 30.0 (n = 43)

144.4 ± 35.7 (n = 141)

Bglu17

9

Glucose-W

5.425

26.37

CEL.9_49183636

168.0 ± 39.8 (n = 42)

134.7 ± 26.5 (n = 62)

146.1 ± 37.1 (n = 124)

Hdlq5

1

HDL-C

8.64

93.52

rs13476259

49.5 ± 20.9 (n = 60)

73.2 ± 26.5 (n = 62)

55.1 ± 19.4 (n = 106)

Hdlcl1

7

HDL-C

2.668

61.33

rs3724711

49.0 ± 20.0 (n = 50)

58.3 ± 21.0 (n = 63)

62.9 ± 25.5 (n = 115)

Hdlq17

9

HDL-C

4.614

30.37

CEL.9_49183636

49.5 ± 15.9 (n = 42)

69.4 ± 26.8 (n = 62)

56.2 ± 22.5 (n = 124)

Hdlq26

10

HDL-C

2.181

61.22

rs3688351

50.7 ± 19.2 (n = 60)

59.4 ± 21.9 (n = 53)

62.4 ± 25.8 (n = 114)

Hdlq5

1

sqrtHDL-W

13.944

87.52

r[55]s3685643

66.6 ± 50.2 (n = 57)

201.1 ± 118.8 (n = 62)

117.0 ± 97.1 (n = 109)

Hdlcl1

7

sqrtHDL-W

3.658

85.57

rs6216320

95.5 ± 87.6 (n = 63)

173.3 ± 126.7 (n = 55)

122.4 ± 98.4 (n = 110)

Hdlq17

9

sqrtHDL-W

10.625

30.42

CEL.9_49183636

57.6 ± 49.3 (n = 42)

183.3 ± 115.0 (n = 62)

122.8 ± 101.7 (n = 124)

Chol7

1

non-HDL-C

2.093

66.95

rs6354736

279.5 ± 62.8 (n = 56)

257.8 ± 56.9 (n = 57)

251.2 ± 52.1 (n = 114)

Nhdlq15

2

non-HDL-C

2.56

23.86

mCV23209429

273.9 ± 56.1 (n = 55)

238.0 ± 47.0 (n = 53)

262.7 ± 59.0 (n = 120)

Hdlq34

5

non-HDL-C

2.106

19.4

rs3658401

244.5 ± 54.7 (n = 63)

276.0 ± 53.2 (n = 61)

259.3 ± 58.3 (n = 104)

Pnhdlc1

6

non-HDL-C

2.489

57.53

rs13478909

279.6 ± 51.3 (n = 51)

252.0 ± 65.2 (n = 57)

254.8 ± 53.5 (n = 120)

Nhdlq1

8

non-HDL-C

2.221

44.14

D8Mit50

275.0 ± 54.5 (n = 60)

242.4 ± 57.4 (n = 57)

262.9 ± 55.6 (n = 96)

Nhdlq12

12

non-HDL-C

2.73

39.41

rs6195664

278.6 ± 52.3 (n = 62)

243.8 ± 57.8 (n = 59)

257.4 ± 56.5 (n = 107)

Nhdlq15

2

non-HDL-W

4.79

31.8

rs13476507

954.1 ± 156.0 (n = 56)

806.9 ± 158.2 (n = 47)

915.6 ± 166.1 (n = 125)

Nhdlq11

9

non-HDL-W

2.136

32.37

rs3709825

958.4 ± 211.4 (n = 42)

856.8 ± 165.3 (n = 62)

906.6 ± 149.5 (n = 124)

-

11

non-HDL-W

2.332

1.99

rs4222040

927.3 ± 149.8 (n = 67)

849.0 ± 165.1 (n = 69)

917.0 ± 170.5 (n = 85)

Nhdlq16

16

non-HDL-W

3.99

46.66

rs3721202

820.2 ± 152.7 (n = 56)

931.9 ± 146.4 (n = 52)

928.4 ± 174.6 (n = 120)

Tgq11

2

Triglyceride-C

2.952

26.73

mCV23209429

123.7 ± 35.7 (n = 55)

101.9 ± 34.6 (n = 53)

107.3 ± 31.8 (n = 120)

-

5

Triglyceride-C

2.759

80.03

gnf05.120.578

110.2 ± 33.2 (n = 43)

119.3 ± 35.8 (n = 88)

101.6 ± 31.3 (n = 97)

Trglyd

1

Triglyceride-W

3.291

97.02

rs13476259

94.0 ± 28.6 (n = 59)

115.3 ± 33.0 (n = 62)

100.7 ± 30.8 (n = 106)

  1. Chr chromosome, LOD logarithm of odds, C chow diet, W Western diet, BB homozygous BALB allele, SS homozygous SM allele, SM heterozygous allele
  2. Data are mean ± SD. The units for these measurements are mg/dL for plasma glucose or lipid levels. The number in the brackets represents the number of progeny with a specific genotype at a peak marker. The significant QTLs and their LOD scores were highlighted in bold