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Table 1 Significant and suggestive QTLs for plasma glucose and lipid levels in female F2 mice derived from BALB-Apoe −/− and SM-Apoe −/− mice

From: Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains

Locus

Chr

Trait

LODa

p-valueb

Peak (cM)

95 % CIc

High allele

Mode of inheritenced

Bglu16

9

Glucose-C

2.214

0.549

2.37

0.37–30.37

B

Additive

Bglu13

5

Glucose-W

2.1.8

<0.63

67.4

45.4–80.03

S

Recessive

-

5

Glucose-W

3.198

0.097

101.24

29.40–101.24

S

Additive

Bglu16

9

Glucose-W

3.12

<0.63

2.37

0–10.37

B

Additive

Bglu17

9

Glucose-W

5.425

0.001

26.37

16.37–40.37

B

Additive

Hdlq5

1

HDL-C

8.64

0.000

93.52

87.52–97.02

S

Additive

Hdlcl1

7

HDL-C

2.668

0.321

61.33

35.57–89.57

S

Dominant

Hdlq17

9

HDL-C

4.614

0.014

30.37

16.37–32.37

S

Additive

Hdlq26

10

HDL-C

2.181

0.591

61.22

25.03–61.22

S

Dominant

Hdlq5

1

HDL-W

13.944

0.000

87.52

83.52–93.52

S

Additive

Hdlcl1

7

HDL-W

3.658

0.034

85.57

77.57–89.67

S

Additive

Hdlq17

9

HDL-W

10.625

0.000

30.42

24.37–30.53

S

Additive

Chol7

1

non-HDL-C

2.093

0.626

66.95

9.52–74.56

B

Recessive

Nhdlq15

2

non-HDL-C

2.56

0.321

23.86

8.73–38.73

B

Additive

Hdlq34

5

non-HDL-C

2.106

0.614

19.4

19.4–30.5

S

Additive

Pnhdlc1

6

non-HDL-C

2.489

0.362

57.53

1.53–77.53

B

Recessive

Nhdlq1

8

non-HDL-C

2.221

0.537

44.14

10.14–60.14

B

Additive

Nhdlq12

12

non-HDL-C

2.73

0.245

39.41

15.41–59.41

B

Additive

Nhdlq15

2

non-HDL-W

4.79

0.002

31.80

22.73–40.73

B

Dominant

Nhdlq11

9

non-HDL-W

2.136

0.585

32.37

0.37–75.33

B

Additive

-

11

non-HDL-W

2.332

0.436

1.99

1.99–17.99

B

Dominant

Nhdlq16

16

non-HDL-W

3.99

0.011

46.66

35.43–46.66

S

Dominant

Tgq11

2

Triglyceride-C

2.952

0.169

26.73

12.73–60.83

B

Additive

-

5

Triglyceride-C

2.759

0.234

80.03

73.40–93.40

S

Heterosis

Trglyd

1

Triglyceride-W

3.291

0.091

97.02

79.24–97.02

S

Additive

  1. aLOD scores were obtained from genome-wide QTL analysis using J/qtl software. The significant LOD scores were highlighted in bold. The suggestive and significant LOD score thresholds were determined by 1,000 permutation tests for each trait. Suggestive and significant LOD scores were 2.116 and 3.429, respectively, for glucose on the chow diet; 2.056 and 3.569 for glucose on the Western diet; 2.127 and 3.725 for HDL cholesterol, 2.09 and 3.662 for non-HDL cholesterol, and 2.102 and 3.522 for triglyceride on the chow diet; 2.10 and 3.486 for HDL, 2.123 and 3.628 for non-HDL, and 2.123 and 3.628 for triglyceride on the Western diet
  2. bThe p-values reported represent the level of genome-wide significance
  3. c95 % Confidence interval in cM defined by a whole genome QTL scan
  4. dMode of inheritance was defined according to allelic effect at the nearest marker of a QTL
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