Fig. 4
From: Leveraging local ancestry to detect gene-gene interactions in genome-wide data
Power comparison for multiple causal SNPs per locus. Power across 25,000 replicates using a Bonferroni correction resulting in p-value thresholds of 1 × 10−7 and 1 × 10−15 for the local ancestry-based interaction test (S L ) and the SNP-based interaction test (S G ), respectively. One to five common causals SNPs were selected per interacting locus while assuming either low (a), moderate (b) or high (c) differentiation of those SNPs between the two admixed populations. We considered three case scenarios for the additional increase in sample size that would be achieve when using local ancestry derived from AIMs, no increase (pink), a lower bound of six fold increase (light red) and an upper bound of 10 fold increase. We varied the baseline sample size (for S G ) across scenarios to emphasize the differences between the tests