Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle

Table 2 Proportion of genetic variance attributable to haplotypes associated with ANAI₄

BTA	BTA SNP and indel-id	positon (bp) _UMD3,1^a	Q/q haplotype	Number of animals genotyped for the haplotype	Minor allele frequency	Heritability	Haplotype effect on total genetic variance^b	Haplotype substitution P-value^d effect^c	P-value^d
2	g. 48476925C>T and g.48476943_48476946insGGC	48476925 and 48476943. 48476946	T and GCC/C and (-)	1433	0.39	0.02	0.1	0.02	0.017

^aThe positions shown are based on the UMD3.1 assembly of the bovine genome.
^bThe effects of the haplotype were estimated as the least-square means from GLM analysis. The statistical model for GLM analysis included the fixed variables of the farm, birth year, and haplotype. The genetic variance explained by the haplotype was calculated based on estimates of the haplotype effect and the haplotype frequency [55]. Total genetic variance was estimated using the MTDF-REML programs. The effect size of haplotype was estimated as the proportion of genetic variance explained by the haplotype.
^cThe average ANAI₄ values for QQ and qq were 0.69 and 0.65, respectively.
^dResults were tested by a 1-way ANOVA, followed by the Tukey–Kramer test for multiple comparisons

ISSN: 2730-6844