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Table 5 Meta-analysis results1 between MESA2 and HRS3 (p-values < 1×10−5) for repeated measures depressive symptom score GEE analyses

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

Race CHR SNP Location Coded allele Coded allele frequency Z-score P-value Direction4,5 Closest gene6 within ±50kB
African American
  1 rs10776776 114384683 T 0.55 4.73 2.30×10−6 ++ (SYT6)
  1 rs1417303 235193008 T 0.59 −4.43 9.46×10−6 -- LOC440737
  2 rs4629180 101454802 A 0.83 −4.51 6.41×10−6 -- (LOC731220)
  2 rs6711630 126534599 T 0.93 4.58 4.70×10−6 ++  
  7 rs10249133 12514004 T 0.39 −4.47 7.67×10−6 -- (LOC100133035)
  8 rs17067630 3661853 A 0.85 4.70 2.57×10−6 ++ CSMD1
  11 rs11036016 40661316 A 0.80 4.68 2.94×10−6 ++ LRRC4C
  15 rs4551976 49264445 T 0.63 −4.45 8.48×10−6 -- (CYP19A1)
  16 rs365962 85267450 C 0.69 −4.53 5.83×10−6 -- (LOC101928614)
  20 rs2426733 55454729 A 0.40 −4.75 2.07×10−6 -- (RBM38)
European American
  1 rs12031875 71357685 A 0.82 4.81 1.54×10−6 ++ ZRANB2-AS2
  4 rs6842756 185341452 A 0.92 4.98 6.54×10−7 ++ ENPP6
  6 rs6941340 16145531 T 0.48 −4.47 7.95×10−6 --  
  9 rs11794102 111772109 A 0.91 4.54 5.70×10−6 ++ PALM2-AKAP2
  13 rs6492314 110267411 C 0.28 −4.75 2.00×10−6 --  
  16 rs12921740 20219533 T 0.51 −4.55 5.44×10−6 -- (GP2)
  18 rs2612547 41290709 A 0.83 4.47 7.94×10−6 ++ SLC14A2
All samples
  1 rs2300177 71270950 T 0.19 −4.56 5.09×10−6 ? − +−−? PTGER3
  1 rs1539418 145676734 A 0.16 −4.53 5.87×10−6 ----??  
  1 rs7415169 168997688 A 0.85 4.70 2.58×10−6 ++++++  
  2 rs6711630 126534599 T 0.93 4.58 4.70×10−6 +????+  
  2 rs41379347 191577187 T 0.89 −5.22 1.81×10−7 ??--?? STAT1
  4 rs6552764 185341497 A 0.86 4.64 3.41×10−6 − + ? − ++ ENPP6
  8 rs12541177 124869454 T 0.31 −4.48 7.43×10−6 ------ FAM91A1
  9 rs9408311 38704682 T 0.84 4.92 8.87×10−7 ++ − +++  
  15 rs16975781 94245464 T 0.90 4.62 3.83×10−6 +++++−  
  16 rs12921740 20219533 T 0.59 −4.70 2.61×10−6 -−− + −− (GP2)
  1. 1Filtered at ethnicity-specific minor allele frequency of 5 %, where the SNP was present in at least two ethnicities, linkage disequilibrium R2 < 80 %, and heterogeneity p-value ≥ 0.1; 2Multi-Ethnic Study of Atherosclerosis; 3Health and Retirement Study 4Order corresponding to direction positions: African, European, Chinese, Hispanic American; 5For all samples analyses, order corresponding to direction position: MESA African American, MESA European American, MESA Chinese American, MESA Hispanic American, HRS European American, HRS African American; 6parentheses indicate location outside of gene