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Table 2 Minimum p-value from GWAS of baseline, averaged, and repeated measures of CES-D1 across ethnicities, MESA2 and HRS3

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

    Baseline CES-D score Averaged CES-D score Repeated measures CES-D score
Study Ethnicity # of SNPS Min # of λ5 Min # of unique SNPs λ Min # of unique SNPs λ
p-value unique SNPs4 p-value p-value
MESA
 African American 2380122 2.05×10−7 7 1.01 6.64×10−7 9 1.00 1.63×10−7 11 1.01
 European American 2166730 1.33×10−7 9 1.01 8.26×10−7 6 1.00 6.04×10−7 11 1.01
 Chinese American 1801470 2.48×10−6 1 0.99 1.42×10−6 2 1.00 2.71×10−7 4 1.02
 Hispanic American 2148331 3.85×10−8 10 1.00 1.61×10−6 4 1.00 9.25×10−7 11 1.01
HRS
 African American 2446939 - - - - - - 2.07×10−6 - 1.01
 European American 2177692 - - - - - - 6.54×10−7 - 1.04
  1. 1Center for Epidemiological Studies – Depression, 2Multi-Ethnic Study of Atherosclerosis, 3Health and Retirement Study, 4Number of unique (independent) SNPs, linkage disequilibrium R2 < 0.80, INFO > 0.80, with ethnicity-specific minor allele frequency > 5 % and p-values < 1×10−5, 5genomic control lambda