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Table 2 Minimum p-value from GWAS of baseline, averaged, and repeated measures of CES-D1 across ethnicities, MESA2 and HRS3

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

   

Baseline CES-D score

Averaged CES-D score

Repeated measures CES-D score

Study

Ethnicity

# of SNPS

Min

# of

λ5

Min

# of unique SNPs

λ

Min

# of unique SNPs

λ

p-value

unique SNPs4

p-value

p-value

MESA

 African American

2380122

2.05×10−7

7

1.01

6.64×10−7

9

1.00

1.63×10−7

11

1.01

 European American

2166730

1.33×10−7

9

1.01

8.26×10−7

6

1.00

6.04×10−7

11

1.01

 Chinese American

1801470

2.48×10−6

1

0.99

1.42×10−6

2

1.00

2.71×10−7

4

1.02

 Hispanic American

2148331

3.85×10−8

10

1.00

1.61×10−6

4

1.00

9.25×10−7

11

1.01

HRS

 African American

2446939

-

-

-

-

-

-

2.07×10−6

-

1.01

 European American

2177692

-

-

-

-

-

-

6.54×10−7

-

1.04

  1. 1Center for Epidemiological Studies – Depression, 2Multi-Ethnic Study of Atherosclerosis, 3Health and Retirement Study, 4Number of unique (independent) SNPs, linkage disequilibrium R2 < 0.80, INFO > 0.80, with ethnicity-specific minor allele frequency > 5 % and p-values < 1×10−5, 5genomic control lambda