Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population

Yang, Wen-Yi; Petit, Thibault; Thijs, Lutgarde; Zhang, Zhen-Yu; Jacobs, Lotte; Hara, Azusa; Wei, Fang-Fei; Salvi, Erika; Citterio, Lorena; Delli Carpini, Simona; Gu, Yu-Mei; Knez, Judita; Cauwenberghs, Nicholas; Barcella, Matteo; Barlassina, Cristina; Manunta, Paolo; Coppiello, Giulia; Aranguren, Xabier L.; Kuznetsova, Tatiana; Cusi, Daniele; Verhamme, Peter; Luttun, Aernout; Staessen, Jan A.

doi:10.1186/s12863-015-0272-2

BMC Genomic Data

Table 2 Multivariable-adjusted hazard ratios for CHD by MEOX2 SNPs

From: Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population

SNP Event	N° events/at risk		Hazard ratio	P	P _BH
SNP Event	Minor allele carriers	Major allele homozygotes	Hazard ratio	P	P _BH
rs10777	*GG + TG*	TT
All coronary events	59/911	47/1116	1.56 (1.06–2.29)	0.024	0.029
Myocardial infarction	31	22	1.75 (1.01–3.03)	0.045	0.054
Coronary revascularisation	42	36	1.42 (0.90–2.24)	0.13	0.14
Ischaemic cardiomyopathy	16	6	4.68 (1.86–11.77)	0.0011	0.0066
rs12056299	*TT + CT*	CC
All coronary events	51/764	55/1263	1.68 (1.17–2.41)	0.0052	0.016
Myocardial infarction	28	25	2.05 (1.20–3.51)	0.0087	0.042
Coronary revascularisation	37	41	1.59 (1.02–2.49)	0.041	0.082
Ischaemic cardiomyopathy	14	8	3.37 (1.49–7.62)	0.0036	0.011
rs7787043	*CC + TC*	TT
All coronary events	74/1111	32/916	1.72 (1.13–2.62)	0.011	0.023
Myocardial infarction	38	15	1.82 (1.02–3.27)	0.044	0.054
Coronary revascularisation	54	24	1.68 (1.02–2.77)	0.041	0.082
Ischaemic cardiomyopathy	16	6	2.22 (0.84–5.86)	0.11	0.20
rs4532497	*CC + TC*	TT
All coronary events	66/1004	40/1023	1.80 (1.22–2.66)	0.0031	0.016
Myocardial infarction	33	20	1.88 (1.03–3.42)	0.040	0.054
Coronary revascularisation	50	28	1.88 (1.20–2.96)	0.0062	0.037
Ischaemic cardiomyopathy	14	8	1.97 (0.80–4.83)	0.14	0.20
rs6959056	*AA + GA*	GG
All coronary events	59/1382	47/645	0.62 (0.42–0.92)	0.017	0.025
Myocardial infarction	27	26	0.52 (0.31–0.88)	0.014	0.042
Coronary revascularisation	46	32	0.71 (0.45–1.12)	0.14	0.14
Ischaemic cardiomyopathy	12	10	0.75 (0.33–1.70)	0.49	0.49
rs1050290	*CC + TC*	TT
All coronary events	73/1194	33/833	1.50 (1.00–2.26)	0.049	0.049
Myocardial infarction	36	17	1.48 (0.81–2.70)	0.20	0.20
Coronary revascularisation	55	23	1.59 (0.99–2.56)	0.055	0.083
Ischaemic cardiomyopathy	16	6	1.97 (0.75–5.16)	0.17	0.20

Numbers of events do not add up, because only the first event in each category was analysed. Hazard ratios (95 % confidence interval) express the risk of minor allele carriers vs. major allele homozygotes, account for family clusters, and were adjusted for baseline characteristics including sex, age, body mass index, systolic pressure, total-to-HDL cholesterol ratio, smoking and drinking, and antihypertensive drug treatment. P and P _BH indicate the significance of the hazard ratios without and with Benjamini-Hochberg’s correction for multiple testing

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