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Table 2 Multivariable-adjusted hazard ratios for CHD by MEOX2 SNPs

From: Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population

SNP Event N° events/at risk Hazard ratio P P BH
Minor allele carriers Major allele homozygotes
rs10777 GG + TG TT    
 All coronary events 59/911 47/1116 1.56 (1.06–2.29) 0.024 0.029
 Myocardial infarction 31 22 1.75 (1.01–3.03) 0.045 0.054
 Coronary revascularisation 42 36 1.42 (0.90–2.24) 0.13 0.14
 Ischaemic cardiomyopathy 16 6 4.68 (1.86–11.77) 0.0011 0.0066
rs12056299 TT + CT CC    
 All coronary events 51/764 55/1263 1.68 (1.17–2.41) 0.0052 0.016
 Myocardial infarction 28 25 2.05 (1.20–3.51) 0.0087 0.042
 Coronary revascularisation 37 41 1.59 (1.02–2.49) 0.041 0.082
 Ischaemic cardiomyopathy 14 8 3.37 (1.49–7.62) 0.0036 0.011
rs7787043 CC + TC TT    
 All coronary events 74/1111 32/916 1.72 (1.13–2.62) 0.011 0.023
 Myocardial infarction 38 15 1.82 (1.02–3.27) 0.044 0.054
 Coronary revascularisation 54 24 1.68 (1.02–2.77) 0.041 0.082
 Ischaemic cardiomyopathy 16 6 2.22 (0.84–5.86) 0.11 0.20
rs4532497 CC + TC TT    
 All coronary events 66/1004 40/1023 1.80 (1.22–2.66) 0.0031 0.016
 Myocardial infarction 33 20 1.88 (1.03–3.42) 0.040 0.054
 Coronary revascularisation 50 28 1.88 (1.20–2.96) 0.0062 0.037
 Ischaemic cardiomyopathy 14 8 1.97 (0.80–4.83) 0.14 0.20
rs6959056 AA + GA GG    
 All coronary events 59/1382 47/645 0.62 (0.42–0.92) 0.017 0.025
 Myocardial infarction 27 26 0.52 (0.31–0.88) 0.014 0.042
 Coronary revascularisation 46 32 0.71 (0.45–1.12) 0.14 0.14
 Ischaemic cardiomyopathy 12 10 0.75 (0.33–1.70) 0.49 0.49
rs1050290 CC + TC TT    
 All coronary events 73/1194 33/833 1.50 (1.00–2.26) 0.049 0.049
 Myocardial infarction 36 17 1.48 (0.81–2.70) 0.20 0.20
 Coronary revascularisation 55 23 1.59 (0.99–2.56) 0.055 0.083
 Ischaemic cardiomyopathy 16 6 1.97 (0.75–5.16) 0.17 0.20
  1. Numbers of events do not add up, because only the first event in each category was analysed. Hazard ratios (95 % confidence interval) express the risk of minor allele carriers vs. major allele homozygotes, account for family clusters, and were adjusted for baseline characteristics including sex, age, body mass index, systolic pressure, total-to-HDL cholesterol ratio, smoking and drinking, and antihypertensive drug treatment. P and P BH indicate the significance of the hazard ratios without and with Benjamini-Hochberg’s correction for multiple testing