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Table 1 Analysis of initial body weight, age and gender on disease phenotypes

From: Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice

A Survival Time (n = 92) Change in BW day 1 (n = 92)
Initial body weight r = 0.192 P > 0.05 r = 0.010 P > 0.05
Week’s old r = 0.099 P > 0.05 r = 0.173 P > 0.05
Gender r = 0.070 P > 0.05 r = 0.035 P > 0.05
B
Mean Survival Time
  Male Female ANOVA
  Mean SEM n Mean SEM n P value
A/J 1.83 0.60 3 4.67 1.06 6 P > 0.05
IL 4052 1.83 0.33 3 1.50 0.00 3 P > 0.05
IL 3438 7.00 0.00 3 7.00 0.00 3 P > 0.05
IL 2156 7.00 0.00 3 3.67 1.69 3 P > 0.05
IL 711 1.50 0.00 2 1.30 0.12 5 P > 0.05
IL 2126 1.50 0.00 4 1.50 0.00 2 P > 0.05
IL 4141 4.25 2.75 2 4.50 1.46 4 P > 0.05
IL 4457 5.17 1.36 3 2.50 0.00 2 P > 0.05
IL 1912 1.17 0.17 3 2.00 0.50 3 P > 0.05
% Change in body weight day 1
  Male Female ANOVA
  Mean SEM n Mean SEM n P value
A/J −10.53 5.90 2 −11.30 1.11 5 P > 0.05
IL 4052 −3.05 0.94 3 −6.37 0.91 3 P > 0.05
IL 3438 −6.52 0.79 3 −4.28 0.47 3 P > 0.05
IL 2156 −5.69 1.75 3 −5.18 1.41 3 P > 0.05
IL 711 −5.13 1.30 2 −5.10 1.23 2 P > 0.05
IL 2126 −6.18 1.19 4 −5.15 0.49 2 P > 0.05
IL 4141 −8.45 1.27 2 −6.62 0.43 4 P > 0.05
IL 4457 −3.76 1.41 3 −5.23 2.03 2 P > 0.05
IL 1912 −6.36 0.00 1 −6.29 0.59 3 P > 0.05
  1. Overall Spearman‘s correlation (r correlation coefficients and P value) between all the initial parameters (initial BW, week’s old and gender) of CC lines and recorded traits (ST: n = 92, CBW1: n = 92) to determine potential influence (A). Two-way ANOVA’s comparison across eight selected CC lines and A/J commercial inbred line to evaluate gender influence on recorded traits (MST and CWB1) (B)
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