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Fig. 1 | BMC Genetics

Fig. 1

From: Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach

Fig. 1

BosNet construction. Information compiled from the different databases was modeled as an undirected graph (N1, N2, N3, N4). Each of the nodes and vertices represents an interaction between a protein pair. The score associated with the graph interaction from each database is represented by a different specific source (i.e., expression level, sequence homology, or conserved domains). Because of differences in the measurement scales, standardization was required. New scores were assigned according to the reported functional annotations (Gene Ontology) between interacting proteins. Finally, the different graphs were integrated to create an integrated functional network of interactions between proteins. The final scores were calculated by assigning greater values to interactions that were represented in more than one database

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